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Lack of Association between Postoperative Pancreatitis and Other Postoperative Complications Following Pancreaticoduodenectomy

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Abstract
Background: Prediction of post-pancreaticoduodenectomy (PD) morbidity is difficult, especially in the early postoperative period when CT (Computed Tomography) scans are not available. Elevated serum amylase and lipase in postoperative day 0 or 1 may be used to define postoperative acute pancreatitis (POAP), but the existing literature does not agree on whether POAP is significantly associated with postoperative pancreatic fistula (POPF). Methods: We analyzed the data obtained from a previously published randomized controlled trial. POAP was defined as elevations in serum amylase above 110 U/L on postoperative day 0 or 1. Clinically relevant POAP (CR-POAP) was defined as elevations in C-reactive protein level (CRP) on postoperative day 2 in those with POAP. Postoperative complications including severe complications (Clavien-Dindo >= IIIa), POPF, and clinically relevant POPF (CR-POPF) were analyzed. Results: In 246 patients, POAP did not show significant associations with total postoperative complications (odds ratio (OR) 0.697; 95% CI, 0.360-1.313; p = 0.271), severe complications (OR 0.647; 95% CI, 0.258-1.747; p = 0.367), and CR-POPF (OR 0.998; 95% CI, 0.310-3.886; p = 0.998) in multivariable analysis. Conclusions: In patients undergoing PD, POAP was not significantly associated with postoperative complications including POPF. Caution should be taken when using POAP as a predictor of POPF.
Author(s)
김송철박서영박예종송기병유대광이우형이재훈전은성황대욱
Issued Date
2021
Type
Article
Keyword
amylasespancreatic fistulapancreaticoduodenectomypancreatitispostoperative complications
DOI
10.3390/jcm10061179
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7979
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_fa07bafa5df04922aa4db77ea05e0e13&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Lack%20of%20Association%20between%20Postoperative%20Pancreatitis%20and%20Other%20Postoperative%20Complications%20Following%20Pancreaticoduodenectomy&offset=0&pcAvailability=true
Publisher
JOURNAL OF CLINICAL MEDICINE
Location
스위스
Language
한국어
ISSN
2077-0383
Citation Volume
10
Citation Number
6
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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