Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort
- Abstract
- Purpose: Asthma is a heterogeneous airway disease occurring in children, and it has various clinical phenotypes. A clear differentiation of the clinical phenotypes can provide better asthma management and prediction of asthma prognosis. Little is currently known about asthma phenotypes in Korean children. This study was designed to identify asthma phenotypes in school-aged Korean children.
Methods: This study enrolled 674 children with physician-diagnosed asthma from the Korean childhood Asthma Study (KAS) cohort. The physicians verified the relevant histories of asthma and comorbid diseases, as well as airway lability and hyper-responsiveness from the results of pulmonary function tests and bronchial provocation tests. Questionnaires regarding the participants' baseline characteristics, their environment and self-rating of asthma control were collected at the time of enrollment. Laboratory tests were performed to assess allergy and airway inflammation. Children with asthma were classified by hierarchical cluster analysis.
Results: Of the 674 patients enrolled from the KAS cohort, 447 were included in the cluster analysis. Cluster analysis of these 447 children revealed 4 asthma phenotypes: cluster 1 (n = 216, 48.3%) which was characterized by male-dominant atopic asthma; cluster 2 (n = 79, 17.7%) which was characterized by early-onset atopic asthma with atopic dermatitis; cluster 3 (n = 47,10.5%) which was characterized by puberty-onset, female-dominant atopic asthma with the low lung function; and cluster 4 (n =105, 23.5%) which was characterized by earlyonset, non-atopic dominant asthma.
Conclusions: The asthma phenotypes among Korean children can be classified into 4 distinct clusters. Long-term follow-up with these phenotypes will be needed to define their prognosis and response to treatment.
- Author(s)
- 권지원; 김우경; 김형영; 김환수; 백혜성; 서동인; 서주희; 송대진; 신미용; 신연호; 양현종; 우성일; 유영; 윤지선; 이은; 이주석; 임대현; 장광천; 정성수; 한민규; 엄은진; 김진택; 유진호
- Issued Date
- 2021
- Type
- Article
- Keyword
- Asthma; childhood; phenotype; cluster analysis
- DOI
- 10.4168/aair.2021.13.1.42
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7981
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9699760&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Heterogeneity%20of%20Childhood%20Asthma%20in%20Korea:%20Cluster%20Analysis%20of%20the%20Korean%20Childhood%20Asthma%20Study%20Cohort&offset=0&pcAvailability=true
- Publisher
- ALLERGY ASTHMA IMMUNOLOGY RESEARCH
- Location
- 대한민국
- Language
- 영어
- ISSN
- 2092-7355
- Citation Volume
- 13
- Citation Number
- 1
- Citation Start Page
- 42
- Citation End Page
- 55
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