Acetazolamide-eluting biodegradable tubular stent prevents pancreaticojejunal anastomotic leakage
- Abstract
- Postoperative pancreatic fistula at the early stage can lead to auto-digestion, which may delay the recovery of the pancreaticojejunal (PJ) anastomosis. The efficacy and safety of an acetazolamide-eluting biodegradable tubular stent (AZ-BTS) for the prevention of self-digestion and intra-abdominal inflammatory diseases caused by pancreatic juice leakage after PJ anastomosis in a porcine model were investigated. The AZ-BTS was successfully fabricated using a multiple dip-coating process. Then, the drug amount and release profile were analyzed. The therapeutic effects of AZ were examined in vitro using two kinds of pancreatic cancer cell lines, AsPC-1 and PANC-1. The efficacy of AZ-BTS was assessed in a porcine PJ leakage model, with animals were each assigned to a leakage group, a BTS group and an AZ-BTS group. The overall mortality rates in these three groups were 44.4%, 16.6%, and 0%, respectively. Mean alpha-amylase concentrations were significantly higher in the leakage and BTS groups than in the AZ-BTS group on day 2-5 (p < 0.05 each all). The luminal diameters and areas of the pancreatic duct were significantly larger in the leakage group than in the BTS and AZ-BTS groups (p < 0.05 each all). These findings indicate that AZ-BTS can significantly suppress intra-abdominal inflammatory diseases caused by pancreatic juice leakage and also prevent late stricture formation at the PJ anastomotic site in a porcine model.
- Author(s)
- 박정훈; 박지은; 박예종; 강전민; 유대성; 경정수; 장종권; 황창모; 심인경; 송호영; 양수근; 김송철
- Issued Date
- 2021
- Type
- Article
- Keyword
- Acetazolamide; Analysis; Inflammation; Pancreas; Pancreatic cancer; Pancreaticojejunal anastomosis; Postoperative pancreatic fistula; Stent (Surgery); Stents
- DOI
- 10.1016/j.jconrel.2021.06.010
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7987
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2540512951&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Acetazolamide-eluting%20biodegradable%20tubular%20stent%20prevents%20pancreaticojejunal%20anastomotic%20leakage&offset=0&pcAvailability=true
- Publisher
- JOURNAL OF CONTROLLED RELEASE
- Location
- 미국
- Language
- 영어
- ISSN
- 0168-3659
- Citation Volume
- 335
- Citation Number
- 1
- Citation Start Page
- 650
- Citation End Page
- 659
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- Medicine > Medicine
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