KLI

Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: a Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group

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Alternative Title
Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: a Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group
Abstract
Purpose: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.

Materials and methods: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.

Results: Of 801 acute myeloid leukemia(AML) children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3-18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had WBC count greater than 10x109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid (ATRA) and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 (86.8%) patients achieved complete remission (CR) after induction chemotherapy. The causes of death were 3 intracranial hemorrhage (ICH), 1 cerebral infarction, and 1 sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival rate (EFS) and overall survival rates (OS) were 82.1 ± 4.4%, 89.7 ± 5.1% respectively. The 4-yr OS was significantly higher in patients with initial WBC <10x109/L than in those with initial WBC ≥10x109/L (p=0.02).

Conclusion: This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.
Author(s)
강형진고경남공섬김구홍회국훈김보람김석구김지윤김혜리류철주박경미박상규박은실박지경백희조신희영심예지유근희이재민이재욱임영탁임재영임호준정낙균조빈주희영최영배최은진최정윤한승민한정우홍경택Eu Jeen Yang
Issued Date
2021
Type
Article
Keyword
E-pub으로 KRI 관계로 사전 승인 Acute promyelocytic leukemiaAll-trans retinoic acidChildhood
DOI
10.4143/crt.2021.313
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8003
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9917926&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Clinical%20Characteristics%20and%20Treatment%20Outcomes%20of%20Childhood%20Acute%20Promyelocytic%20Leukemia%20in%20Korea:%20a%20Nationwide%20Multicenter%20Retrospective%20Study%20by%20Korean%20Pediatric%20Oncology%20Study%20Group&amp;offset=0&amp;pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
한국어
ISSN
1598-2998
Citation Volume
10
Citation Number
4143
Citation Start Page
2021.313
Citation End Page
2021.313
Appears in Collections:
Medicine > Medicine
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