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FDG-PET patterns associated with ideomotor apraxia and imitation apraxia in patients with corticobasal syndrome

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Abstract
Introduction: Apraxia is a core clinical feature of corticobasal syndrome (CBS). Among the subtypes of apraxia, ideomotor and imitation apraxia are frequently found in CBS. However, little is known about the brain networks that are characteristic of each apraxia subtype or their clinical implication. In this study, we used 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to explore the specific patterns of glucose hypometabolism that are characteristic of apraxia subtypes by focusing on ideomotor and imitation apraxia. Methods: We compared the areas of glucose hypometabolism in the brains of 52 patients with CBS and 13 healthy controls, both as a whole and according to apraxia subtypes. In addition, we investigated the relationship between the apraxia subtypes and the clinical phenotype of CBS. Results: In patients with CBS, common hypometabolism was observed in the frontal gyrus, precentral gyrus and caudate regardless of apraxia subtypes. In particular, ideomotor apraxia was associated with hypometabolism in the angular gyrus, while imitation apraxia was associated with hypometabolism in the posterior part including the postcentral gyrus, precuneus, and posterior cingulate gyrus. Patients who showed both ideomotor and imitation apraxia were more likely to show the typical features of CBS and progressive supranuclear palsy compared with patients showing only one type of apraxia Conclusion: Group comparison analysis using FDG-PET revealed distinct pathways of ideomotor and imitation apraxia in CBS. These findings add to our understanding of the brain networks underlying apraxia in association with the clinical features of CBS.
Author(s)
강동화권미선김재승김형지오민영오정수이선주이재홍이종식정선주정이내조성양
Issued Date
2021
Type
Article
Keyword
Corticobasal syndromeFDG positron emission tomographyIdeomotor apraxiaImitation apraxia
DOI
10.1016/j.parkreldis.2021.06.006
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8009
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2545603691&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,FDG-PET%20patterns%20associated%20with%20ideomotor%20apraxia%20and%20imitation%20apraxia%20in%20patients%20with%20corticobasal%20syndrome&offset=0&pcAvailability=true
Publisher
PARKINSONISM RELATED DISORDERS
Location
네덜란드
Language
영어
ISSN
1353-8020
Citation Volume
88
Citation Number
88
Citation Start Page
96
Citation End Page
101
Appears in Collections:
Medicine > Medicine
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