Ultraviolet A light effectively reduces bacteria and viruses including coronavirus
- Abstract
- Antimicrobial-resistant and novel pathogens continue to emerge, outpacing efforts to contain
and treat them. Therefore, there is a crucial need for safe and effective therapies. Ultraviolet-
A (UVA) phototherapy is FDA-approved for several dermatological diseases but not
for internal applications. We investigated UVA effects on human cells in vitro, mouse colonic
tissue in vivo, and UVA efficacy against bacteria, yeast, coxsackievirus group B and coronavirus-
229E. Several pathogens and virally transfected human cells were exposed to a series
of specific UVA exposure regimens. HeLa, alveolar and primary human tracheal epithelial
cell viability was assessed after UVA exposure, and 8-Oxo-2’-deoxyguanosine was measured
as an oxidative DNA damage marker. Furthermore, wild-type mice were exposed to
intracolonic UVA as an in vivo model to assess safety of internal UVA exposure. Controlled
UVA exposure yielded significant reductions in Pseudomonas aeruginosa, Klebsiella pneumoniae,
Escherichia coli, Enterococcus faecalis, Clostridioides difficile, Streptococcus pyogenes,
Staphylococcus epidermidis, Proteus mirabilis and Candida albicans. UVA-treated
coxsackievirus-transfected HeLa cells exhibited significantly increased cell survival compared
to controls. UVA-treated coronavirus-229E-transfected tracheal cells exhibited significant
coronavirus spike protein reduction, increased mitochondrial antiviral-signaling protein
and decreased coronavirus-229E-induced cell death. Specific controlled UVA exposure had
no significant effect on growth or 8-Oxo-2’-deoxyguanosine levels in three types of human
cells. Single or repeated in vivo intraluminal UVA exposure produced no discernible endoscopic,
histologic or dysplastic changes in mice. These findings suggest that, under specific
conditions, UVA reduces various pathogens including coronavirus-229E, and may provide a
safe and effective treatment for infectious diseases of internal viscera. Clinical studies are
warranted to further elucidate the safety and efficacy of UVA in humans.
- Author(s)
- Ali Rezaie
- Issued Date
- 2021
- Type
- Article
- Keyword
- ultraviolet; irradiation; bacteria; virus
- DOI
- 10.1371/journal.pone.0237782
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8015
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_plos_journals_2432836718&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Ultraviolet%20A%20light%20effectively%20reduces%20bacteria%20and%20viruses%20including%20coronavirus&offset=0&pcAvailability=true
- Publisher
- PLoS One
- Location
- 미국
- Language
- 영어
- ISSN
- 1932-6203
- Citation Volume
- 15
- Citation Number
- 8
- Citation Start Page
- 1
- Citation End Page
- 19
-
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