KLI

Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions

Metadata Downloads
Abstract
Abstract


Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to immunotherapy. In this systematic review, we assessed the potential predictive role of high-TMB in pancreatic ductal adenocarcinoma (PDAC), as well as the histo-molecular features of high-TMB PDAC. High-TMB appeared as a rare but not-negligible molecular feature in PDAC, being present in about 1.1% of cases. This genetic condition was closely associated with mucinous/colloid and medullary histology (p < 0.01). PDAC with high-TMB frequently harbored other actionable alterations, with microsatellite instability/defective mismatch repair as the most common. Immunotherapy has shown promising results in high-TMB PDAC, but the sample size of high-TMB PDAC treated so far is quite small. This study highlights interesting peculiarities of PDAC harboring high-TMB and may represent a reliable starting point for the assessment of TMB in the clinical management of patients affected by pancreatic cancer.
Author(s)
홍승모Aldo ScarpaAndrea MafficiniAntonio PeaClaudio LuchiniGiovanni MarchegianiGiuseppe MalleoJae Il ShinLodewijk A. BrosensMaria L. PireddaMichele MilellaPaola MattioloRita T. LawlorRoberto SalviaSergio V. TaorminaValentyna Kryklyva
Issued Date
2021
Type
Article
Keyword
immunotherapypancreatic cancerPD-1PD-L1ReviewTMBTMLtumor mutation burden
DOI
10.3390/cancers13133119
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8028
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_48386a8ee633462490d0f8b1c7585191&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Tumor%20Mutational%20Burden%20as%20a%20Potential%20Biomarker%20for%20Immunotherapy%20in%20Pancreatic%20Cancer:%20Systematic%20Review%20and%20Still-Open%20Questions&amp;offset=0&amp;pcAvailability=true
Publisher
Cancers
Location
스위스
Language
영어
ISSN
2072-6694
Citation Volume
13
Citation Number
13
Citation Start Page
3119
Citation End Page
3119
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.