KLI

Prognostic implication of SOX2 expression in small intestinal adenocarcinoma

Metadata Downloads
Abstract
The presence of KRAS mutation enhances the stem cell features of colorectal carcinoma cells containing mutant adenomatous polyposis coli (APC). However, their potential role in small intestinal adenocarcinoma remains elusive. Here, we aimed to investigate the clinical significance of cancer stem cell markers?expression in the context of small intestinal adenocarcinoma with the KRAS genotype. SOX2, NANOG, and OCT4 expression were assessed by immunohistochemistry and digital image analysis, and their potential association with KRAS was further examined in 185 Korean patients with small intestinal adenocarcinomas, which were collected from 22 institutions in South Korea. Positive expression of SOX2, NANOG, and OCT4 was detected in 65 (35.1%), 94 (50.8%), and 82 (44.3%) of patients, respectively. Patients with high SOX2 (SOX2+) expression displayed worse overall survival compared to those with low SOX2 (SOX2?) expression?(P < 0.001). Patients with SOX2+/mutant KRAS (KRAS
Author(s)
홍승모Jeong Won KimJoon-Yong ChungKris YlayaStephen M. HewittSun-Young JunYoonho Park
Issued Date
2021
Type
Article
Keyword
MedicineMedicine &amp; Public HealthOriginal ArticlePathology
DOI
10.1007/s00428-020-02946-x
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8032
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2454406805&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Prognostic%20implication%20of%20SOX2%20expression%20in%20small%20intestinal%20adenocarcinoma&amp;offset=0&amp;pcAvailability=true
Publisher
VIRCHOWS ARCHIV
Location
독일
Language
영어
ISSN
0945-6317
Citation Volume
478
Citation Number
6
Citation Start Page
1049
Citation End Page
1060
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.