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Optimizing palliative chemotherapy for advanced invasive mucinous adenocarcinoma of the lung

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Abstract
BackgroundA primary pulmonary invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive adenocarcinoma of the lung. The prognosis of advanced IMA depending on chemotherapy regimen has not been fully investigated. Here, we compared the clinical outcomes of patients with advanced IMA treated with different palliative chemotherapies that included novel therapeutics.MethodsThis single-center retrospective study included a total of 79 patients diagnosed with IMA and treated with palliative chemotherapy. The primary outcome was the comparison of overall survival according to palliative chemotherapy type. Risk factors associated with death were evaluated as a secondary outcome.ResultsThe study cohort of 79 patients comprised 27 progressive or recurrent cases and 52 initial metastatic patients. Thirteen patients (16.5%) received targeted therapy and 18 cases (22.8%) received immunotherapy. When we compared the survival outcomes of the different treatment regimens, patients with IMA treated by immunotherapy (undefined vs. non-immunotherapy 17.0months, p<0.001) had better overall survival rates. However, there was no difference in the prognosis between the cases treated with a targeted therapy (35.6 vs. non-targeted therapy 17.0months, p=0.211). None of the conventional regimens produced a better outcome. By multivariable analysis, immunotherapy (HR 0.28; 95% CI 0.11-0.74; P=0.008) was found to be an independent prognostic factor for death.ConclusionsThis study suggests that immunotherapy for patients with advanced IMA may provide favorable outcomes than other chemotherapy options.
Author(s)
김상위김우성윤신교이대호이재철장윤정지원준최창민현동건
Issued Date
2021
Type
Article
Keyword
AdenocarcinomaAdenocarcinoma of the lungCancerCare and treatmentChemotherapyComparative analysisDevelopment and progressionDrug therapyHealth aspectsImmunotherapyLung cancerMedical researchMedicineExperimentalMetastasisMethodsMucinousPalliative treatmentPatient outcomesPrognosisStage IVTreatment outcome
DOI
10.1186/s12885-021-08472-6
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8044
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_09e44b5dac3e41878a50da627eca73fd&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Optimizing%20palliative%20chemotherapy%20for%20advanced%20invasive%20mucinous%20adenocarcinoma%20of%20the%20lung&amp;offset=0&amp;pcAvailability=true
Publisher
BMC CANCER
Location
영국
Language
영어
ISSN
1471-2407
Citation Volume
21
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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