Single-Center Experience of Living Donor Liver Transplantation for Patients With Secondary Biliary Cirrhosis
- Background. Secondary biliary cirrhosis (SBC) represents a unique form of cirrhosis that develops in the liver secondary to persistent biliary obstruction. This study aimed to review the living donor liver transplants (LDLTs) performed at our center for patients with SBC and end-stage liver disease and to share the perioperative strategies undertaken to achieve satisfactory outcomes.
Methods. The medical records of 29 patients who underwent LDLT for SBC between December 1994 and July 2018 at the Asan Medical Center (Seoul, South Korea) were retrospectively reviewed. Their clinical data were extracted and statistically analyzed. Survival curves were computed.
Results. The perioperative and in-hospital morbidity rates were 72.4% and 10.3%, respectively. The overall mean recipient follow-up was 80.0 (SD, 66.4) months (range, 0.8-246.8 months). Patient survival rates after 1, 3, 5, and 10 years after transplant were 82.8%, 79.3%, 79.3%, and 79.3%, respectively. For liver grafts, the survival rates were 82.8%, 75.8%, 75.8%, and 75.8% at 1, 3, 5, and 10 years, respectively.
Conclusions. LDLT is potentially a final lifesaving resort for patients with SBC with portal hypertension. However, considering the difficulty of surgery and perioperative management, LDLT should be performed by experienced transplant surgeons in a center where a multidisciplinary approach is possible.
- 김기훈; 문덕복; 박길춘; 박정익; 송기원; 안철수; 윤영인; 이승규; 장진기; 정동환; 하태용; 황신
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- Adult; Analysis; Biliary cirrhosis; Care and treatment; Donation of organs; tissues; etc; End Stage Liver Disease - pathology; End Stage Liver Disease - surgery; Female; Humans; Hypertension; Liver Cirrhosis; Biliary - pathology; Liver Cirrhosis; Biliary - surgery; Liver Transplantation - methods; Liver Transplantation - mortality; Living Donors; Male; Medical colleges; Medical records; Middle Aged; Republic of Korea; Retrospective Studies; Transplantation of organs; tissues; etc
- TRANSPLANTATION PROCEEDINGS
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