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Longitudinal follow-up of serum biomarkers in patients with neuromyelitis optica spectrum disorder

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Abstract
--------------------e-pub (22.1.12)----------------
Background:
Recently, several serum biomarkers have been proposed in Neuromyelitis Optica Spectrum Disorders (NMOSD) to monitor disease activity.
Objective:
The objective of the study is to evaluate the longitudinal clinical value of serum biomarkers in patients with NMOSD.

Methods:
We prospectively recruited consecutive NMOSD patients with anti-aquaporin-4 antibody and obtained serum samples at enrollment, after 6?12?months of follow-up (main period), and at attacks. Using single-molecule array assays, we evaluated longitudinal changes of serum neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and GFAP/NfL levels.

Results:
Overall, 64 patients (58 women) were enrolled (age: 51?years, disease duration: 6.7?years) and 133 samples were obtained. Among patients who did not develop new attacks during the main period (n?=?62), serum levels of NfL, GFAP, and GFAP/NfL were significantly decreased over time in patients with attacks (<2?months) at enrollment (n?=?14 (23%)), whereas serum NfL and GFAP levels gradually increased in the others (n?=?48 (77%)). During the study, five (8%) patients developed new attacks; only serum GFAP levels increased consistently upon these events compared with baseline levels. To differentiate attacks from remissions, serum GFAP levels showed the largest area under the receiver operating characteristic curve (0.876, 95% confidence interval: 0.801?0.951).

Conclusion:
Among NfL, GFAP, and GFAP/NfL, serum GFAP might be the most appropriate for monitoring NMOSD longitudinally, which warrants future confirming studies.
Author(s)
김광국김승미김현지김현진김혜원문성신서다영이은재임영민정규윤최린경
Issued Date
2021
Type
Article
Keyword
Glial fibrillary acidic proteinneurofilament light chainneuromyelitis optica spectrum disorderserum biomarkers
DOI
10.1177/13524585211024978
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8052
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2548416266&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Longitudinal%20follow-up%20of%20serum%20biomarkers%20in%20patients%20with%20neuromyelitis%20optica%20spectrum%20disorder&amp;offset=0&amp;pcAvailability=true
Publisher
Multiple Sclerosis Journal
Location
영국
Language
영어
ISSN
1352-4585
Citation Volume
00
Citation Number
0
Citation Start Page
1
Citation End Page
10
Appears in Collections:
Medicine > Medicine
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