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Combined Chemoembolization and Radiotherapy Versus Chemoembolization Alone for Hepatocellular Carcinoma Invading the Hepatic Vein or Inferior Vena Cava

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Abstract
Purpose To evaluate the efficacy and safety of transarterial chemoembolization (TACE) plus radiotherapy compared with TACE alone for patients with hepatocellular carcinoma (HCC) invading the hepatic vein (HV) or inferior vena cava (IVC). Materials and Methods Data from 79 patients who underwent TACE plus radiotherapy as a first-line treatment for non-metastatic HCC invading the HV or IVC between 2006 and 2018 were retrospectively evaluated. These findings were compared with data from a historical control group, consisting of 80 patients who received TACE alone between 2000 and 2006. Results Baseline characteristics were similar in both groups. Median progression-free survival (PFS) (8.1 vs. 4.4 months, P = 0.003) and overall survival (OS) (18.3 vs. 9.5 months, P = 0.002) were longer in the TACE plus radiotherapy than in the TACE alone group. Multivariate analysis showed that PFS and OS were significantly associated with treatment type. Subgroup analyses found that TACE plus radiotherapy showed better OS than TACE alone in patients with Child-Pugh class A, maximal tumor size < 9 cm, tumor number < 4, serum alpha-fetoprotein level >= 400 ng/mL, infiltrative tumor, IVC tumor thrombus, and combined portal vein invasion. The major complication rates were similar between the TACE plus radiotherapy (16.5%) and the TACE alone (13.8%) group (P = 0.664) Conclusion Both TACE plus radiotherapy and TACE alone showed similar safety in treating non-metastatic HCC invading the HV or IVC. TACE plus radiotherapy seems effective to prolong OS and PFS compared to TACE alone in this specific patient group.
Author(s)
고흥규권동일김진형김평화심주현윤상민추희호Alrashidi Ibrahim
Issued Date
2021
Type
Article
Keyword
AnalysisBlood clotCancerCardiologyCare and treatmentClinical InvestigationGlycoproteinsHepatomaImagingInterventional OncologyLiverMedical collegesMedicineMedicine &amp; Public HealthMetastasisNuclear MedicineRadiologyRadiotherapyThrombosisUltrasound
DOI
10.1007/s00270-021-02815-3
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8056
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2503679739&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Combined%20Chemoembolization%20and%20Radiotherapy%20Versus%20Chemoembolization%20Alone%20for%20Hepatocellular%20Carcinoma%20Invading%20the%20Hepatic%20Vein%20or%20Inferior%20Vena%20Cava&amp;offset=0&amp;pcAvailability=true
Publisher
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Location
미국
Language
영어
ISSN
0174-1551
Citation Volume
44
Citation Number
7
Citation Start Page
1060
Citation End Page
1069
Appears in Collections:
Medicine > Medicine
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