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Second allogeneic hematopoietic stem cell transplantation in patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation

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Abstract
The prognosis of patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) is dismal. We aimed to evaluate the outcomes and prognostic factors of the second HSCT (HSCT2) in acute leukemia patients relapsed after the first HSCT (HSCT1). We analyzed 80 patients who received HSCT2 for relapsed acute leukemia in two Korean institutes. All but four patients received HSCT2 from a donor other than matched sibling donor: an unrelated donor (URD) in 30 and a familial haploidentical donor (FHD) in 46. Forty-four patients (55.0%) were in complete remission (CR) or CR with incomplete count recovery (CRi) at HSCT2, and the median time from HSCT1 to relapse was 9 months. The 2-year overall survival (OS) and event-free survival (EFS) were 21.0% and 17.5%, respectively. The outcomes were similar between URD and FHD. Multivariate analysis demonstrated that disease status (active disease vs. CR/CRi) at HSCT2 and remission duration after HSCT1 were independent prognostic factors for OS and EFS after HSCT2. HSCT2 from URD or FHD was feasible in patients with acute leukemia relapsed after allogeneic HSCT. Also, our study confirmed two critical prognostic factors; disease status at HSCT2 and remission duration after HSCT1.
Author(s)
최윤숙최은지이정희이규형조재철박한승이유진설미이이영신강영아전미진이제환
Issued Date
2021
Type
Article
Keyword
acuteleukemiaoutcomesprognostic factorsrelapsesecond allogeneic stem cell transplantation
DOI
10.1111/ctr.14199
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8066
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2472106868&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Second%20allogeneic%20hematopoietic%20stem%20cell%20transplantation%20in%20patients%20with%20acute%20leukemia%20relapsed%20after%20allogeneic%20hematopoietic%20stem%20cell%20transplantation&offset=0&pcAvailability=true
Publisher
CLINICAL TRANSPLANTATION
Location
미국
Language
영어
ISSN
0902-0063
Citation Volume
35
Citation Number
3
Citation Start Page
e14199
Citation End Page
e14199
Appears in Collections:
Medicine > Medicine
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