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Chemoembolization for Single Large Hepatocellular Carcinoma with Preserved Liver Function: Analysis of Factors Predicting Clinical Outcomes in a 302 Patient Cohort

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Abstract
The purpose of this study was to define the role of transcatheter arterial chemoembolization (TACE) in patients with a single large hepatocellular carcinoma (HCC) and define the patient groups benefiting from TACE. Treatment-naive patients with preserved liver function who received TACE as the first-line treatment for single large (>5 cm) HCC without macrovascular invasion and extrahepatic metastasis between 2007 and 2019 were retrospectively analyzed. Overall survival, progression-free survival, radiologic tumor response, complications, and predictors of survival were analyzed using multivariate analysis, and then a pretreatment risk-prediction model was created using the four predictive factors of tumor size, tumor type, ALBI grade, and ECOG performance status. Patients with scores of 0 (n = 54), 1-2 (n = 170), and 3-6 (n = 78) according to the model were classified as low-, intermediate-, and high-risk, respectively. The corresponding median OS values were 141, 55, and 28 months, respectively. The percentage of major complications increased as tumor size increased (4-21%). Asymptomatic, nodular HCC patients with a tumor size of 5-7 cm and ALBI grade 1 benefited the most from TACE. By contrast, the value of TACE in the treatment of single huge HCC (>10 cm) with high complication rates remains unclear.
Author(s)
고기영고흥규권동일김건하김진형신지훈심주현윤현기추희호
Issued Date
2021
Type
Article
Keyword
hepatocellular carcinomarisk factorssurvivaltransarterial chemoembolization
DOI
10.3390/life11080840
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8081
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_ed850406c50d490aba912e4445faf394&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Chemoembolization%20for%20Single%20Large%20Hepatocellular%20Carcinoma%20with%20Preserved%20Liver%20Function:%20Analysis%20of%20Factors%20Predicting%20Clinical%20Outcomes%20in%20a%20302%20Patient%20Cohort&offset=0&pcAvailability=true
Publisher
LIFE-BASEL
Location
스위스
Language
영어
ISSN
2075-1729
Citation Volume
11
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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