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Effect of Anodal Transcranial Direct Current Stimulation Combined With Cognitive Training for Improving Cognition and Language Among Children With Cerebral Palsy With Cognitive Impairment: A Pilot, Randomized, Controlled, Double-Blind, and Clinical T

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Abstract
About 30?45% of cerebral palsy (CP) patients have cognitive impairment. Previous
studies showed the evidence that transcranial direct current stimulation (tDCS) may
have some benefits in attention-deficit/hyperactivity disorder, autism spectrum disorder,
and motor development in CP. The aim of this study is to evaluate the effect of
tDCS on cognition, language, and activities of daily living (ADL) among children with
CP with cognitive impairment. It was a pilot, randomized, controlled, double-blind,
clinical trial in a tertiary pediatric hospital, and 13 children with CP and a cognitive age
under 42 months were enrolled. tDCS group (n = 8) had active tDCS and cognitive
training (20 min/session, total 20 sessions, for 12 weeks) and sham group (n = 5) had
sham tDCS and cognitive training. Primary outcome was the Bayley Scales of Infant
Development II (BSID II). Secondary outcomes were the Pediatric Evaluation of Disability
Inventory (PEDI), the Laboratory Temperament Assessment Battery (Lab-TAB), the Early
Childhood Behavior Questionnaire (ECBQ), the Korean version of MacArthur?Bates
Communicative Development Inventories (M-B CDI-K), the Sequenced Language Scale
for Infants (SELSI) and the Preschool Receptive-Expressive Language Scale (PRES).
After intervention, the tDCS group showed significant improvements in all measurements
(p < 0.05) except the M-B CDI-K (grammar), whereas the sham group only showed
significant improvements in the Lab-TAB (manipulation domain), the ECBQ (attentional
shifting), and the M-B CDI-K (comprehension). The between-group differences in the
degree of post-intervention improvement were not statistically significant. The degree of
Ko et al. tDCS in CP for Cognition
improvement was associated with better baseline cognitive function and younger age
(p < 0.05). There were no major adverse events after tDCS. The combined application
of tDCS and cognitive training was feasible and associated with improvements in
cognitive function, ADL, and language among children with CP with cognitive impairment.
However, considering that it is a pilot study, further larger-scale systematic investigation
is needed.
Clinical Trial Registration: The trial was registered in the Clinical Research Information
Service database, identifier: KCT0003023.
Author(s)
고은재성인영염미선육진숙최은정홍미진
Issued Date
2021
Type
Article
Keyword
cerebral palsychildcognitive dysfunctionlanguagetranscranial direct current stimulation
DOI
10.3389/fped.2021.713792
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8089
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_4a0fe676a51248c798edd1614bd90263&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Effect%20of%20Anodal%20Transcranial%20Direct%20Current%20Stimulation%20Combined%20With%20Cognitive%20Training%20for%20Improving%20Cognition%20and%20Language%20Among%20Children%20With%20Cerebral%20Palsy%20With%20Cognitive%20Impairment:%20A%20Pilot,%20Randomized,%20Controlled,%20Double-Blind,%20and%20Clinical%20T&amp;offset=0&amp;pcAvailability=true
Publisher
Frontiers in pediatrics
Location
스위스
Language
영어
ISSN
2296-2360
Citation Volume
9
Citation Number
1
Citation Start Page
1
Citation End Page
10
Appears in Collections:
Medicine > Medicine
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