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Comparison of Antibody and T Cell Responses Induced by Single Doses of ChAdOx1 nCoV-19 and BNT162b2 Vaccines

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Abstract
There are limited data directly comparing humoral and T cell responses to the ChAdOx1 nCoV-19 and BNT162b2 vaccines. We compared Ab and T cell responses after first doses of ChAdOx1 nCoV-19 vs. BNT162b2 vaccines. We enrolled healthcare workers who received ChAdOx1 nCoV-19 or BNT162b2 vaccine in Seoul, Korea. Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein-specific IgG Abs (S1-IgG), neutralizing Abs (NT Abs), and SARS-CoV-2-specific T cell response were evaluated before vaccination and at 1-wk intervals for 3 wks after vaccination. A total of 76 persons, comprising 40 injected with the ChAdOx1 vaccine and 36 injected with the BNT162b2 vaccine, participated in this study. At 3 wks after vaccination, the mean levels (+/- SD) of S1-IgG and NT Abs in the BNT162b2 participants were significantly higher than in the ChAdOx1 participants (S1-IgG, 14.03 +/- 7.20 vs. 6.28 +/- 8.87, p<0.0001; NT Ab, 183.1 +/- 155.6 vs. 116.6 +/- 116.2, p=0.035), respectively. However, the mean values of the T cell responses in the 2 groups were comparable after 2 wks. The humoral immune response after the 1st dose of BNT162b2 developed faster and was stronger than after the 1st dose of ChAdOx1. However, the T cell responses to BNT162b2 and ChAdOx1 were similar.
Author(s)
권지수김성한김지연박순주박지영배성만서미현이나경이현정임소윤지영미차혜희허진영David Shum
Issued Date
2021
Type
Article
Keyword
ImmunogenicityAntibody responseT cell responseChAdOx1 nCoV-19 vaccineBNT162b2 vaccine
DOI
10.4110/in.2021.21.e29
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8094
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9858025&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Comparison%20of%20Antibody%20and%20T%20Cell%20Responses%20Induced%20by%20Single%20Doses%20of%20ChAdOx1%20nCoV-19%20and%20BNT162b2%20Vaccines&amp;offset=0&amp;pcAvailability=true
Publisher
IMMUNE NETWORK
Location
대한민국
Language
한국어
ISSN
1598-2629
Citation Volume
21
Citation Number
4
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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