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Clinical Characteristics and Risk Factors of Early-Onset Tuberculosis After Liver Transplantation

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Abstract
Background. We encountered some cases of early-onset tuberculosis (TB) after liver transplant (LT), leading to further transmission to other immunocompromised patients. Therefore, we investigated the clinical characteristics and risk factors of early-onset TB after LT. Methods. All adult patients with TB after LT from 1996 to 2019 were retrospectively enrolled. Our hospital did not screen for latent TB infection (LTBI) in LT recipients because of concerns regarding the potential hepatotoxicity of anti-TB medication. Patients were categorized into 2 groups based on the TB onset time after LT: early-onset TB (<= 2 months) and late-onset TB (>2 months). Results. Of 4301 LT recipients, 91 patients developed TB after LT (2.1%). The median time from LT to TB development was 9.4 months. Of these 91 patients, 11 were classified as having early-onset TB (12.1%). Patients with early-onset TB had a greater pretransplant TB history than patients with late-onset TB (36.4% vs 11.3%, P = .048). Conclusion. This unusual early-onset TB was more common in patients with a pretransplant TB history, suggesting the possibility of missed TB or full manifestation of the indolent course of TB after LT. Therefore, LT recipients with a pretransplant TB history should undergo thorough screening for active TB and consider prophylaxis.
Author(s)
김기훈김성한박길춘심태선이상오이승규정혜민조경욱
Issued Date
2021
Type
Article
Keyword
Antitubercular agentsLiverMedical collegesMedical researchMedical screeningMedicineExperimentalRisk factorsTransplantationTuberculosis
DOI
10.1016/j.transproceed.2021.04.016
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8102
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2531221576&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Clinical%20Characteristics%20and%20Risk%20Factors%20of%20Early-Onset%20Tuberculosis%20After%20Liver%20Transplantation&amp;offset=0&amp;pcAvailability=true
Publisher
TRANSPLANTATION PROCEEDINGS
Location
미국
Language
영어
ISSN
0041-1345
Citation Volume
53
Citation Number
5
Citation Start Page
1694
Citation End Page
1699
Appears in Collections:
Medicine > Medicine
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