KLI

Gender differences in seizure recurrence and antiepileptic drug polytherapy predicting health-related quality of life of persons 1 year after diagnosis of epilepsy

Metadata Downloads
Abstract
Purpose: The aim of this study was to determine whether gender influences the prediction of health-related quality of life (HRQoL) in persons with newly diagnosed epilepsy (NDE).

Methods: This was a 1-year longitudinal study. Persons with NDE were assessed with the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), the Hospital Anxiety Depression Scale (HADS), the Stigma Scale, and the Rosenberg Self-esteem Scale. An analysis of covariance (ANCOVA) with interaction terms was used.

Results: Among 134 adults with NDE, there were no gender differences in the scores of the QOLIE-31 and its subscales. A multivariate linear regression analysis showed that the HADS-anxiety scores at diagnosis (p = 0.005) and seizure recurrence after diagnosis (p = 0.050) negatively predicted QOLIE-31 scores in persons with NDE. There were significant effects of the gender interaction with seizure recurrence (F = 8.745, p = 0.004, partial eta(2) = 0.066) and antiepileptic drug (AED) polytherapy (F = 6.320, p = 0.013, partial eta(2) = 0.049) in the adjusted model. Specifically, seizure recurrence negatively predicted the QOLIE-31 scores only in men. By contrast, AED polytherapy negatively predicted the QOLIE-31 scores only in women.

Conclusions: There are gender differences in certain epilepsy-related factors predicting HRQoL at 1 year in persons with NDE. (C) 2021 Elsevier Inc. All rights reserved.
Author(s)
이상암Hyung-Kook ParkOk-Joon KimSoo Jeong KimSoon-Kee No
Issued Date
2021
Type
Article
Keyword
Antiepileptic drug polytherapyAnxietyEpilepsyHealth-related quality of lifeNewly diagnosed epilepsySeizure recurrence.
DOI
10.1016/j.yebeh.2021.107984
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8171
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2524358181&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Gender%20differences%20in%20seizure%20recurrence%20and%20antiepileptic%20drug%20polytherapy%20predicting%20health-related%20quality%20of%20life%20of%20persons%201%20year%20after%20diagnosis%20of%20epilepsy&offset=0&pcAvailability=true
Publisher
EPILEPSY BEHAVIOR
Location
미국
Language
영어
ISSN
1525-5050
Citation Volume
120
Citation Number
0
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.