KLI

Pure T-cell mediated rejection following kidney transplant according to response to treatment

Metadata Downloads
Abstract
The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, Delta GFR, TCMR within one year, t score, and IF/TA score. We also found that non-responder vs. responder (OR = 3.31; P = 0.036) and lower GFR at biopsy (OR = 0.56; P = 0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (P = 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment.
Author(s)
고영민권현욱김영훈김효상박수길백충희신성임성준정주희조용필
Issued Date
2021
Type
Article
Keyword
AntibodiesBiopsyDiagnosisDiagnostic systemsGlomerular filtration rateGraft rejectionGraftingGraftsHealth aspectsInformed consentInternal medicineKidney transplantationKidneysLymphocytes TMedical schoolsMedicineNephrologyPancreasPatientsRejectionRisk analysisRisk factorsSurgeryT cellsTransplantationTransplants & implants
DOI
10.1371/journal.pone.0256898
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8175
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_plos_journals_2569042375&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Pure%20T-cell%20mediated%20rejection%20following%20kidney%20transplant%20according%20to%20response%20to%20treatment&offset=0&pcAvailability=true
Publisher
PLOS ONE
Location
미국
Language
한국어
ISSN
1932-6203
Citation Volume
16
Citation Number
9
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.