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The Korean Society for Neuro-Oncology (KSNO) Guideline for Antiepileptic Drug Usage of Brain Tumor: Version 2021.1

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Abstract
Background: To date, there has been no practical guidelines for the prescription of antiepileptic drugs (AEDs) in brain tumor patients in Korea. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing guidelines for AED usage in brain tumors since 2019.

Methods: The Working Group was composed of 27 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of the keywords.

Results: The core contents are as follows. Prophylactic AED administration is not recommended in newly diagnosed brain tumor patients without previous seizure history. When AEDs are administered during peri/postoperative period, it may be tapered off according to the following recommendations. In seizure-naive patients with no postoperative seizure, it is recommended to stop or reduce AED 1 week after surgery. In seizure-naive patients with one early postoperative seizure (<1 week after surgery), it is advisable to maintain AED for at least 3 months before tapering. In seizure-naive patients with ≥2 postoperative seizures or in patients with preoperative seizure history, it is recommended to maintain AEDs for more than 1 year. The possibility of drug interactions should be considered when selecting AEDs in brain tumor patients. Driving can be allowed in brain tumor patients when proven to be seizure-free for more than 1 year.

Conclusion: The KSNO suggests prescribing AEDs in patients with brain tumor based on the current guideline. This guideline will contribute to spreading evidence-based prescription of AEDs in brain tumor patients in Korea.

Keywords: Antiepileptic drug; Brain tumors; Guideline; Korean Society for Neuro-Oncology; Practice.
Author(s)
곽호신김경환김세훈김영일도윤식문장섭박재성박철기서영범성경수송진호위찬우윤완수윤홍인이민호이세훈이윤수임도훈임정호장종희조진모한명훈홍제범김민성김영준황기환박지은김호성KSNO guideline working group
Issued Date
2021
Type
Article
Keyword
Antiepileptic drugBrain tumorsGuidelineKorean Society for Neuro-OncologyPractice.
DOI
10.14791/btrt.2021.9.e7
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8185
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9777196&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,The%20Korean%20Society%20for%20Neuro-Oncology%20(KSNO)%20Guideline%20for%20Antiepileptic%20Drug%20Usage%20of%20Brain%20Tumor:%20Version%202021.1&amp;offset=0&amp;pcAvailability=true
Publisher
Brain Tumor Research and Treatment
Location
대한민국
Language
영어
ISSN
2288-2405
Citation Volume
9
Citation Number
1
Citation Start Page
9
Citation End Page
15
Appears in Collections:
Medicine > Medicine
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