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Treatment of chemotherapy-induced cachexia with BST204: a multimodal validation study

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Abstract
Introduction Chemotherapy is a major etiology of cachexia. Ginseng products are known to have various anti-cachectic and health-promoting effects, such as inhibiting inflammation and promoting energy production. In particular, BST204, purified ginseng dry extract, contains multiple ginsenosides that can reduce chemotherapy-related fatigue and toxicity. Objectives To investigate the effects of BST204 on the alleviation of chemotherapy-induced cachexia using a multimodal approach. Methods In a CT26 mouse syngeneic colon cancer model, cachexia was predominantly induced by chemotherapy with 5-fluorouracil (5-FU) than by tumor growth. BST204 at a dose of 100 or 200 mg/kg was administered to 5-FU-treated mice. Results BST204 significantly mitigated the decrease in tumor-excluded body weight (change in 5-FU group and BST204 groups: - 13% vs. - 6% on day 7; - 30% vs. - 20% on day 11), muscle volume (- 19% vs. - 11%), and fat volume (- 91% vs. - 56%). The anti-cachectic effect of BST204 was histologically demonstrated by an improved balance between muscle regeneration and degeneration and a decrease in muscle cross-sectional area reduction. Conclusion Chemotherapy-induced cachexia was biochemically and metabolically characterized by activated inflammation, enhanced oxidative stress, increased protein degradation, decreased protein stabilization, reduced glucose-mediated energy production, and deactivated glucose-mediated biosynthesis. These adverse effects were significantly improved by BST204 treatment. Overall, our multimodal study demonstrated that BST204 could effectively alleviate chemotherapy-induced cachexia.
Author(s)
김호진김수정우동철유현주김상태우철웅김점용박선규임민주김정곤
Issued Date
2021
Type
Article
Keyword
BST204Chemotherapy-induced cachexiaMultimodal study
DOI
10.1007/s11306-021-01781-8
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8188
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2503630355&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Treatment%20of%20chemotherapy-induced%20cachexia%20with%20BST204:%20a%20multimodal%20validation%20study&offset=0&pcAvailability=true
Publisher
METABOLOMICS
Location
미국
Language
영어
ISSN
1573-3882
Citation Volume
17
Citation Number
4
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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