KLI

Partial unilateral lentiginosis: a clinicopathological analysis of 32 cases on the head and neck area in Korea

Metadata Downloads
Abstract
Background Partial unilateral lentiginosis (PUL) is a rare acquired circumscribed hyperpigmentation characterized by multiple simple lentigines involving half of the body. Since the previous studies of PUL were mostly based on case reports and the current literature lacks well-designed retrospective studies that involve a large number of cases, PUL is not a well-defined entity, and differential diagnosis with nevus spilus is still difficult. This study aims to evaluate clinical and histopathological characteristics and treatment outcomes of PUL on head and neck area of Koreans.

Methods Thirty-two patients with PUL on head and neck area were diagnosed clinicohistopathologically at the Asan Medical Center from 2004 to 2017. Their medical records, photographs, and biopsy specimens were reviewed, and immunohistochemical staining for protein kinase C (PKC)-beta Iota Iota was evaluated for melanogenic activity.

Results Four patients (12.5%) of PUL had congenital lesions, and 24 (75.0%) had age of onset younger than 10 years. Confluency of lentiginous lesions (100%) and mild to moderate background interlesional hyperpigmentation (90.6%) were observed. The lentiginous lesions showed increased melanocytes, melanophages, basal melanins, lentiginous hyperplasia, and perivascular inflammatory cells compared with background interlesional hyperpigmentation, and PKC-beta Iota Iota was focally positive in 7 of 12 stained PUL lesions. Among the 16 patients who received laser treatments, 10 (62.5%) showed more than 50% of improvement.

Conclusions The findings of this study will allow for improved diagnosis of PUL and understanding of its features, which may facilitate proper management in the future.
Author(s)
김학태나형민원종현이미우이우진장성은최명은최지호
Issued Date
2021
Type
Article
Keyword
AnalysisGenetic disordersImmunohistochemistrylasersMedical recordspigmentation disordersProtein kinasestreatment
DOI
10.1111/ijd.15630
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8204
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2531221938&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Partial%20unilateral%20lentiginosis:%20a%20clinicopathological%20analysis%20of%2032%20cases%20on%20the%20head%20and%20neck%20area%20in%20Korea&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF DERMATOLOGY
Location
영국
Language
한국어
ISSN
0011-9059
Citation Volume
60
Citation Number
11
Citation Start Page
1376
Citation End Page
1384
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.