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Clinical outcomes and long-term prognosis of perianal Crohn's disease in an Asian population

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Abstract
Background and Aim: The clinical impact of perianal Crohn’s disease (CD) (pCD), a
wellknown poor prognostic factor of CD, has not been fully evaluated in Asian patients.
We investigated the outcomes of CD in Korean patients according to the presence of
pCD at CD diagnosis.
Methods: Using 2010?2014 data from the national health insurance claims database, we
evaluated the disease course of CD according to the presence of pCD at CD diagnosis.
The results were veried in a hospitalbased cohort of 2923 patients.
Results: The cumulative risk of intestinal resection was lower in patients with pCD at di-
agnosis than in those without, in the populationbased cohort (9.1% vs 14.7% at 5 years
after diagnosis, P < 0.001), but it was similar between the two groups in the
hospitalbased cohort (36.8% vs 36.8% at 10 years after diagnosis, P = 0.950). Moreover,
the cumulative risk of behavioral progression was not signicantly different between the
two groups in the hospitalbased cohort (43.4% vs 41.6% at 10 years after diagnosis,
P = 0.366). On multivariable analysis, pCD at CD diagnosis was not a predictor of intesti-
nal resection, behavioral progression, CDrelated hospital admission, or diverting surgery;
however, it was an independent predictor of proctectomy (hazard ratio [HR] 3.210,
P < 0.001) and anorectal cancer (HR 3.104, P = 0.047).
Conclusions: Although the presence of pCD increased the risk of proctectomy and
anorectal cancer in Asian patients, the clinical impact of pCD on the overall outcomes of
patients with CD may be less signicant in Asian patients compared with Western patients.
Author(s)
김정석명승재박상형변정식송은미양동훈양석균예병덕오은혜이호수함남석황성욱
Issued Date
2021
Type
Article
Keyword
Crohn's diseasePerianal fistulaPrognosis
DOI
10.1111/jgh.15308
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8233
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2454131342&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Clinical%20outcomes%20and%20long-term%20prognosis%20of%20perianal%20Crohn%27s%20disease%20in%20an%20Asian%20population&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Location
오스트레일리아
Language
한국어
ISSN
0815-9319
Citation Volume
36
Citation Number
6
Citation Start Page
1571
Citation End Page
1579
Appears in Collections:
Medicine > Medicine
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