Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea
- Background/Aims: We aimed to evaluate the clinical characteristics and long-term prognosis
of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished
population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods: Clinical characteristics and prognosis were compared between two groups: EOUC,
defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined as
UC diagnosed in individuals aged 18 to 59 years.
Results: We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%)
between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure to
medications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids,
p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumulative
risks of disease outcomes were also comparable between patients with EOUC and N-EOUC
(22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization
[p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate
Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predictor
of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to
28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed
comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those
with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization,
- 박상형; 양석균; 예병덕; Hyuk Yoon; Hyunju Park; Jae Myung Cha; Jeong Hwan Kim; Ji Hyun Lee; Jong Pil Im; Joo Sung Kim; Kyoung Hoon Rhee; Kyung Ho Kim; Seong O Suh; Seung Kyu Jeong; Sun Yong Park; Sung Hoon Kim; Sung Noh Hong; Young Kyun Kim; Young-Ho Kim
- Issued Date
- Colitis; ulcerative; Aged; Prognosis; Korea
- Gut and Liver
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