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Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea

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Abstract
Background/Aims: We aimed to evaluate the clinical characteristics and long-term prognosis
of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished
population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods: Clinical characteristics and prognosis were compared between two groups: EOUC,
defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined as
UC diagnosed in individuals aged 18 to 59 years.
Results: We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%)
between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure to
medications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids,
p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumulative
risks of disease outcomes were also comparable between patients with EOUC and N-EOUC
(22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization
[p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate
Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predictor
of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to
28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed
comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those
with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization,
and colectomy.
Author(s)
박상형양석균예병덕Hyuk YoonHyunju ParkJae Myung ChaJeong Hwan KimJi Hyun LeeJong Pil ImJoo Sung KimKyoung Hoon RheeKyung Ho KimSeong O SuhSeung Kyu JeongSun Yong ParkSung Hoon KimSung Noh HongYoung Kyun KimYoung-Ho Kim
Issued Date
2021
Type
Article
Keyword
ColitisulcerativeAgedPrognosisKorea
DOI
10.5009/gnl20289
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8234
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9861802&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinical%20Characteristics%20and%20Long-term%20Prognosis%20of%20Elderly-Onset%20Ulcerative%20Colitis%20in%20a%20Population-Based%20Cohort%20in%20the%20Songpa-%20Kangdong%20District%20of%20Seoul,%20Korea&offset=0&pcAvailability=true
Publisher
Gut and Liver
Location
대한민국
Language
한국어
ISSN
1976-2283
Citation Volume
15
Citation Number
5
Citation Start Page
742
Citation End Page
751
Appears in Collections:
Medicine > Medicine
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