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Preoperative prediction score of hepatocellular carcinoma recurrence in living donor liver transplantation Validation of SNAPP score developed at Asan Medical Center.

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Abstract
The previously proposed scoring systems are not readily available because of the lack
of simplicity for predicting hepatocellular carcinoma (HCC) recurrence. We aimed to
develop and validate the new score system, which can predict HCC recurrence after
living donor liver transplantation (LDLT) by using morphologic and biologic data.
Predictors for HCC recurrence after LDLT were developed (n = 627) and validated
(n = 806) in 1433 patients for whom we could collect information to date between
2007 and 2016 at Asan Medical center (AMC) to create the SNAPP score (tumor Size
and Number, alpha-fetoprotein [AFP], vitamin K absence-II [PIVKA-II], positron emission tomography [PET]). On logistic regression based on 3-year recurrence-free survival, the SNAPP factors were independently associated with HCC recurrence. The
SNAPP score was highly predictive of HCC recurrence (C statistic, 0.920), and 5-year
post-LT recurrence rates were significantly different between low, intermediate, and
high SNAPP score groups. The performance of the SNAPP score (C-index [95% confidence interval], 0.840 [0.801-0.876]) on predicting tumor recurrence after LDLT was
better than that of the New York/California, the Risk Estimation of Tumor Recurrence
After Transplant (RETREAT), and the Model of Recurrence After Liver Transplant
(MoRAL) score. The SNAPP score provides excellent prognostication after LDLT for
HCC patients. Hence, we can help voluntary patients’ decisions about whether to undergo LDLT or not
Author(s)
김기훈김석환김화정문덕복박길춘송기원안철수윤영인이승규정동환하태용황신
Issued Date
2021
Type
Article
Keyword
Analysiscancer/malignancy/neoplasiaclassification systemsclinical research/practiceDiseasesDonation of organstissuesetcHepatomaLiverliver disease: malignantliver transplantation/hepatologyliver transplantation: living donorMedical centersRelapseTransplantation
DOI
10.1111/ajt.16227
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8239
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A653814494&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Preoperative%20prediction%20score%20of%20hepatocellular%20carcinoma%20recurrence%20in%20living%20donor%20liver%20transplantation%20Validation%20of%20SNAPP%20score%20developed%20at%20Asan%20Medical%20Center.&offset=0&pcAvailability=true
Publisher
AMERICAN JOURNAL OF TRANSPLANTATION
Location
미국
Language
영어
ISSN
1600-6135
Citation Volume
21
Citation Number
2
Citation Start Page
604
Citation End Page
613
Appears in Collections:
Medicine > Medicine
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