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Association of Stage 1 Hypertension Defined by the ACC/AHA 2017 Guideline With Asymptomatic Coronary Atherosclerosis

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Abstract
BACKGROUND This study sought to assess the relationship between stage 1 hypertension and subclinical coronary atherosclerosis.

METHODS A total of 4,666 individuals with available coronary computed tomography angiography (CCTA) results from a health checkup were enrolled. The classification of hypertension was adapted from the American College of Cardiology/American Heart Association (ACC/AHA) 2017 guideline. The presence of coronary plaques and its characteristics, and other CCTA findings were assessed.

RESULTS There was a linear relationship between blood pressure (BP), both systolic BP (SBP) and diastolic BP (DBP), and the presence of coronary plaque. Patients were classified into 4 groups according to the BP category: normal BP (SBP <120 mm Hg and DBP <80 mm Hg; n = 2,395; 51.3%), elevated BP (SBP 120-129 mm Hg and DBP <80 mm Hg; n = 467; 10.0%), stage 1 hypertension (SBP 130-139 mm Hg or DBP 80-89 mm Hg; n = 1,139; 24.4%), and stage 2 hypertension (SBP >= 140 mm Hg or DBP >= 90 mm Hg; n = 665; 14.2%). Compared with the normal BP group after multivariate adjustment, the stage 1 hypertension group was significantly associated with the presence of atherosclerotic plaque (adjusted odds ratio [95% confidential interval], 1.37 [1.17-1.62]; P < 0.001), especially in noncalcified and mixed plaques. The relationship between stage 1 hypertension and stenosis >50% was not statistically significant. Isolated diastolic and isolated systolic stage 1 hypertensions were significantly related to the presence of coronary plaque. The elevated BP group was not associated with any positive CCTA findings.

CONCLUSIONS Stage 1 hypertension was independently associated with subclinical coronary atherosclerosis.
Author(s)
김영학김주현노재형박경민윤용훈이승환이재환이종영이필형이한별최재원
Issued Date
2021
Type
Article
DOI
10.1093/ajh/hpab051
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8244
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2503445812&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Association%20of%20Stage%201%20Hypertension%20Defined%20by%20the%20ACC%2FAHA%202017%20Guideline%20With%20Asymptomatic%20Coronary%20Atherosclerosis&amp;offset=0&amp;pcAvailability=true
Publisher
AMERICAN JOURNAL OF HYPERTENSION
Location
미국
Language
영어
ISSN
0895-7061
Citation Volume
34
Citation Number
4
Citation Start Page
858
Citation End Page
866
Appears in Collections:
Medicine > Medicine
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