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Nocturnal stridor in multiple system atrophy: Video-polysomnography and clinical features

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Abstract
Introduction: Nocturnal stridor, a life-threatening condition linked to respiratory failure and sudden death during sleep, is a serious issue in patients with multiple system atrophy (MSA). However, little is known about polysomnographic findings and clinical features of MSA patients with nocturnal stridor. Hence, we investigated video-polysomnography (VPSG) findings and clinical features associated with nocturnal stridor in patients with MSA. Methods: We retrospectively analyzed the clinical data of patients with MSA (n = 49) who underwent overnight VPSG for the evaluation of sleep-disordered breathing. The presence of nocturnal stridor was confirmed based on overnight VPSG findings. Clinical data, including VPSG findings and clinical features, were compared between MSA patients with and without nocturnal stridor. Results: Nocturnal stridor was present in 31 (63.3%) patients with MSA. Patients with stridor showed significantly higher apnea-hypopnea, respiratory disturbance, and oxygen desaturation indices than those without stridor (P = 0.024, P = 0.049, and P = 0.006, respectively). Patients with stridor had more severe axial motor features, more impaired activities of daily living, and longer disease duration than those without stridor (P = 0.012, P = 0.036, and P = 0.003, respectively). However, there were no significant between-group differences in sex, age at disease onset, MSA subtype, parkinsonian features, cerebellar ataxia, residual urine volume, or systolic and diastolic blood pressure change. Conclusions: MSA with nocturnal stridor is related to higher apnea indices in conjunction with higher O2 desaturation index, more severe axial motor features, more impaired activities of daily living, and longer disease duration.
Author(s)
김효재이상암정선주Ho-Sung RyuJuyeon KimKiju KimMi-Jung KimSooyeoun YouYoung Jin Kim
Issued Date
2021
Type
Article
Keyword
Axial motor featuresMultiple system atrophyNocturnal stridorVideo-polysomnography
DOI
10.1016/j.parkreldis.2021.03.015
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8252
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2548914359&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Nocturnal%20stridor%20in%20multiple%20system%20atrophy:%20Video-polysomnography%20and%20clinical%20features&offset=0&pcAvailability=true
Publisher
PARKINSONISM RELATED DISORDERS
Location
영국
Language
영어
ISSN
1353-8020
Citation Volume
89
Citation Number
0
Citation Start Page
48
Citation End Page
53
Appears in Collections:
Medicine > Medicine
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