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Sorafenib Combined with Chemoembolization for Locally Advanced Hepatocellular Carcinoma with Macroscopic Vascular Invasion: A Propensity Score Analysis

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Abstract
The purpose of this study was to compare the efficacy and safety of transarterial chemoembolization (TACE) plus sorafenib with those of TACE alone in patients with locally advanced hepatocellular carcinoma (HCC). Treatment-naive patients with preserved hepatic reserve (Child?Pugh score ≤ 7) who received TACE plus sorafenib (n = 91) or TACE alone (n = 109) for locally advanced HCC with macrovascular invasion were retrospectively evaluated. Propensity score matching (PSM) was used to correct selection bias, and 63 pairs were created. In the entire study population, the median progression-free survival (PFS) and overall survival (OS) with TACE plus sorafenib were better than those with TACE alone. After PSM, the median PFS (7.0 vs. 4.3 months; p = 0.017) and OS (17.5 vs. 12.8 months; p = 0.049) were again significantly longer with TACE plus sorafenib than with TACE alone. Stratified Cox regression analysis and doubly robust estimation revealed that treatment type was significantly associated with both PFS and OS. In the subgroup analysis, TACE plus sorafenib did not show a significant survival benefit for patients with main portal vein or inferior vena cava invasion. Major complications were similar in both groups (p = 0.330). In conclusion, TACE plus sorafenib showed better survival outcomes than TACE alone in patients with locally advanced HCC.
Author(s)
김건하김나영김진형심주현최상림Alali Meshari
Issued Date
2021
Type
Article
Keyword
hepatocellular carcinomamacroscopic vascular invasionsorafenibtransarterial chemoembolization
DOI
10.3390/life11101066
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8257
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_f2ae6d959a6c4253827562a0bac98e17&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Sorafenib%20Combined%20with%20Chemoembolization%20for%20Locally%20Advanced%20Hepatocellular%20Carcinoma%20with%20Macroscopic%20Vascular%20Invasion:%20A%20Propensity%20Score%20Analysis&offset=0&pcAvailability=true
Publisher
Life(Basel)
Location
스위스
Language
영어
ISSN
2075-1729
Citation Volume
11
Citation Number
10
Citation Start Page
1066
Citation End Page
1066
Appears in Collections:
Medicine > Medicine
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