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Clinically Applicable Serum Biomarkers Among 14 Candidates Associated With Recurrence of Stage II and III Colorectal Cancer

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Abstract
Background/aim: We evaluated the predictive value of candidate serum biomarkers for recurrence in stage II and III colorectal cancer (CRC) after curative surgery.

Patients and methods: A total of 33 and 120 patients with CRC with or without recurrence at 5 years after curative surgery were included in the training set and the validation set, respectively. Possible serum biomarkers were examined for associations with CRC recurrence using receiver operating characteristics (ROC) curve analysis.

Results: In the training set, the expression levels of the 14 biomarkers were compared according to recurrence. Among them, five biomarkers that had significantly different expression levels were validated in 60 patients with recurrence at 5 years after curative surgery and 60 patients without. Multivariate analysis showed that natural log-transformed values of carcinoembryonic antigen (CEA), cyclin-dependent kinase regulatory subunit 2 (CKS2), 2'-5'-oligoadenylate synthetase 2 (OAS2), and autophagy-related gene 5 (ATG5) in preoperative serum were significantly related to recurrence. ROC analysis showed that these biomarkers were able to discriminate patients with recurrence from those without (area under the curve=0.828, 95% confidence interval=0.755-0.990).

Conclusion: Preoperative serum levels of CEA, CKS2, OAS2 and ATG5 were independent risk factors for recurrence. A combination of serum CEA, CKS2, OAS2 and ATG5 predicted tumor recurrence well in patients with stage II and III CRC.

Keywords: ATG5; CEA; CKS2; Colorectal cancer; OAS2; biomarkers; recurrence.
Author(s)
김선규김용성김진천김찬욱노선애조동형탁가희하예진
Issued Date
2021
Type
Article
Keyword
ATG5CEACKS2Colorectal cancerOAS2biomarkersrecurrence.
DOI
10.21873/anticanres.15279
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8278
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_21873_anticanres_15279&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinically%20Applicable%20Serum%20Biomarkers%20Among%2014%20Candidates%20Associated%20With%20Recurrence%20of%20Stage%20II%20and%20III%20Colorectal%20Cancer&offset=0&pcAvailability=true
Publisher
ANTICANCER RESEARCH
Location
그리스
Language
한국어
ISSN
0250-7005
Citation Volume
41
Citation Number
9
Citation Start Page
4651
Citation End Page
4658
Appears in Collections:
Medicine > Medicine
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