KLI

The Prognostic Value of Programmed Death-ligand 1 (PD-L1) in Patients who Received Neoadjuvant Chemoradiation Therapy Followed by Surgery for Locally Advanced Non-small Cell Lung Cancer

Metadata Downloads
Abstract
Background/Aim: We analyzed the prognostic efficacy of programmed death-ligand 1 (PD-L1) in locally advanced non-small cell lung cancer (LA-NSCLC) patients. Patients and Methods: During 2005-2016, 211 patients underwent neoadjuvant concurrent chemoradiation therapy (CCRT) followed by surgical resection for LA-NSCLC at Asan Medical Center. PD-L1 expression and CD8+ tumor infiltrating lymphocytes (TIL) were measured pre-and post-neoadjuvant CCRT and analyzed using immunohistochemical staining. Results: In total, 39 patients were enrolled. Overall survival (OS) and disease-free survival (DFS) were significantly longer in patients with increased PD-L1 expression and increased CD8+ TIL density postneoadjuvant CCRT. Univariate Cox regression analysis confirmed that increased levels of PD-L1 and increased CD8+ TIL density were prognostic factors for OS and DFS. Multivariate Cox regression analysis confirmed that increased levels of PD-L1 was a prognostic factor for OS and increased CD8+ TIL density for DFS. Conclusion: Relative changes in PD-L1 expression post-neoadjuvant CCRT can be utilized to predict the prognosis of LANSCLC patients.
Author(s)
김형렬송준선이근동장세진정병권
Issued Date
2021
Type
Article
Keyword
Non-small cell lung cancerprognosisprogrammed death ligand-1tumor-infiltrating lymphocytesneoadjuvant therapy
DOI
10.21873/anticanres.15106
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8286
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_21873_anticanres_15106&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20Prognostic%20Value%20of%20Programmed%20Death-ligand%201%20(PD-L1)%20in%20Patients%20who%20Received%20Neoadjuvant%20Chemoradiation%20Therapy%20Followed%20by%20Surgery%20for%20Locally%20Advanced%20Non-small%20Cell%20Lung%20Cancer&offset=0&pcAvailability=true
Publisher
ANTICANCER RESEARCH
Location
인도
Language
영어
ISSN
0250-7005
Citation Volume
41
Citation Number
6
Citation Start Page
3193
Citation End Page
3204
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.