KLI

Prediction model for cervical lymph node metastasis in human papillomavirus-related oropharyngeal squamous cell carcinomas

Metadata Downloads
Abstract
Objectives To develop and validate a risk scoring system based on clinical and imaging findings to predict lymph node metastasis from HPV-related oropharyngeal squamous cell carcinomas. Methods This study population who had undergone neck dissections or lymph node biopsies in patients with HPV+ OPSCC was obtained from a historical cohort from two tertiary referral hospitals. The training set from one hospital included 455 lymph nodes from 82 patients, and the test set from the other hospital included 150 lymph nodes from 42 patients. The baseline clinical and imaging findings on pretreatment CT or MR were investigated and the reference standards were the histopathologic results. A risk scoring system was constructed based on logistic regression and validated both internally and externally. Results A 7-point risk scoring system was developed based on the following variables: central necrosis, infiltration of adjacent planes, lymph node level, and the maximal axial diameter of the lymph node. This risk scoring system showed good discriminative ability for metastasis in the training set (C-statistic 0.952; 95% CI, 0.931-0.972) and test set (C-statistic 0.968, 95% CI, 0.936-0.999) and good calibration ability in the training set (p = 0.723) and test set (p = 0.253). Conclusions We developed and validated a reliable risk scoring system that predicts lymph node metastasis from HPV+ OPSCCs based on the clinical data and pretreatment imaging findings. We expect this risk scoring system to be a useful guide for better decision-making in practice.
Author(s)
김선옥배윤정백정환서종현이윤세이정현정새롬주리히최영준
Issued Date
2021
Type
Article
Keyword
Human papillomavirusLymph nodesMagnetic resonance imagingOropharyngeal cancerTomographyX-ray computed
DOI
10.1007/s00330-021-07766-4
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8303
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2506519061&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prediction%20model%20for%20cervical%20lymph%20node%20metastasis%20in%20human%20papillomavirus-related%20oropharyngeal%20squamous%20cell%20carcinomas&offset=0&pcAvailability=true
Publisher
EUROPEAN RADIOLOGY
Location
오스트리아
Language
한국어
ISSN
0938-7994
Citation Volume
31
Citation Number
10
Citation Start Page
7429
Citation End Page
7439
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.