Demographics, Changes in Treatment Patterns, and Outcomes of Bone and Soft Tissue Sarcomas in Korea-A Sarcoma-Specific, Institutional Registry-Based Analysis
- Abstract
- Purpose: Because of the heterogeneity of sarcomas, establishing a well-collected, sarcoma specific database is important for sarcoma research. We analyzed the first histology-based, sarcoma-specific institutional registry in Korea, which collected 28 years of patient data according to a predefined data format. Patients and Methods: Adult bone and soft tissue sarcoma patients who were treated from June 1989 to January 2017 were identified and analyzed, based on the ICD-O-3 codes. Results: Among the 3420 patients included, soft tissue and bone sarcomas comprised 77.8% (n = 2661) and 22.2% (n = 759), respectively. Median age at diagnosis was 50 (range, 16-98) in soft tissue sarcomas and 37 (range, 16-85) in bone sarcomas. Males and females comprised 45.5% and 54.5% of soft tissue sarcomas and 52.7% and 47.3% of bone sarcomas, respectively. Among the 3407 patients with treatment data available, 90.5% of the patients with soft tissue sarcomas and 80.8% of the patients with bone sarcomas received surgery first, of which 57.8% and 71.7% did not receive any subsequent treatment, respectively. Overall, the proportion of patients who received surgery alone decreased from 85.7% to 60.5% from the pre-2000 period to the 2010-2017 period. However, the use of adjuvant chemotherapy increased in patients with soft tissue sarcomas (from 8.0% to 17.2% in the same period), and the use of perioperative radiotherapy also increased in both groups (from 1.4% to 22.7% in soft tissue sarcomas, and 0% to 14.5% in bone sarcomas in the same period). In both soft tissue and bone sarcomas, old age (>= 65 years) and diagnosis in the early study period were associated with poorer survival. Conclusion: We presented a comprehensive summary of our sarcoma registry, including the demographics, changes in treatment patterns, and survival outcomes. This study will provide a framework for future studies.
- Author(s)
- 김완림; 김정은; 송시열; 송준선; 안진희; 이민희; 이종석; 임형수; 정혜원; 정혜현; 조경자
- Issued Date
- 2021
- Type
- Article
- Keyword
- BONE SARCOMA; SOFT TISSUE SARCOMA; REAL-WORLD EVIDENCE
- DOI
- 10.2147/CMAR.S337606
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8340
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_6604c257f6dc47bc87f09542fe40a816&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Demographics,%20Changes%20in%20Treatment%20Patterns,%20and%20Outcomes%20of%20Bone%20and%20Soft%20Tissue%20Sarcomas%20in%20Korea-A%20Sarcoma-Specific,%20Institutional%20Registry-Based%20Analysis&offset=0&pcAvailability=true
- Publisher
- CANCER MANAGEMENT AND RESEARCH
- Location
- 뉴질랜드
- Language
- 한국어
- ISSN
- 1179-1322
- Citation Volume
- 13
- Citation Start Page
- 8795
- Citation End Page
- 8802
-
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- Medicine > Medicine
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