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Demographics, Changes in Treatment Patterns, and Outcomes of Bone and Soft Tissue Sarcomas in Korea-A Sarcoma-Specific, Institutional Registry-Based Analysis

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Abstract
Purpose: Because of the heterogeneity of sarcomas, establishing a well-collected, sarcoma specific database is important for sarcoma research. We analyzed the first histology-based, sarcoma-specific institutional registry in Korea, which collected 28 years of patient data according to a predefined data format. Patients and Methods: Adult bone and soft tissue sarcoma patients who were treated from June 1989 to January 2017 were identified and analyzed, based on the ICD-O-3 codes. Results: Among the 3420 patients included, soft tissue and bone sarcomas comprised 77.8% (n = 2661) and 22.2% (n = 759), respectively. Median age at diagnosis was 50 (range, 16-98) in soft tissue sarcomas and 37 (range, 16-85) in bone sarcomas. Males and females comprised 45.5% and 54.5% of soft tissue sarcomas and 52.7% and 47.3% of bone sarcomas, respectively. Among the 3407 patients with treatment data available, 90.5% of the patients with soft tissue sarcomas and 80.8% of the patients with bone sarcomas received surgery first, of which 57.8% and 71.7% did not receive any subsequent treatment, respectively. Overall, the proportion of patients who received surgery alone decreased from 85.7% to 60.5% from the pre-2000 period to the 2010-2017 period. However, the use of adjuvant chemotherapy increased in patients with soft tissue sarcomas (from 8.0% to 17.2% in the same period), and the use of perioperative radiotherapy also increased in both groups (from 1.4% to 22.7% in soft tissue sarcomas, and 0% to 14.5% in bone sarcomas in the same period). In both soft tissue and bone sarcomas, old age (>= 65 years) and diagnosis in the early study period were associated with poorer survival. Conclusion: We presented a comprehensive summary of our sarcoma registry, including the demographics, changes in treatment patterns, and survival outcomes. This study will provide a framework for future studies.
Author(s)
김완림김정은송시열송준선안진희이민희이종석임형수정혜원정혜현조경자
Issued Date
2021
Type
Article
Keyword
BONE SARCOMASOFT TISSUE SARCOMAREAL-WORLD EVIDENCE
DOI
10.2147/CMAR.S337606
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8340
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_6604c257f6dc47bc87f09542fe40a816&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Demographics,%20Changes%20in%20Treatment%20Patterns,%20and%20Outcomes%20of%20Bone%20and%20Soft%20Tissue%20Sarcomas%20in%20Korea-A%20Sarcoma-Specific,%20Institutional%20Registry-Based%20Analysis&offset=0&pcAvailability=true
Publisher
CANCER MANAGEMENT AND RESEARCH
Location
뉴질랜드
Language
한국어
ISSN
1179-1322
Citation Volume
13
Citation Start Page
8795
Citation End Page
8802
Appears in Collections:
Medicine > Medicine
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