Risk Factors for High-Grade Meningioma in Brain and Spine: Systematic Review and Meta-analysis
- BACKGROUND: Histologic grade has important implications for the management in meningioma. It is important to understand the risk of high-grade meningioma (grades II and III). In this article, we systematically reviewed the histologic grade of meningioma depending on the location and sex and its relationship with recurrence. METHODS: The PubMed and Embase databases were systematically searched until February 4, 2020. We included studies that were not restricted to specific anatomic locations, histologic grade, or the sizes of the tumors. The proportion of high-grade meningiomas depending on the location and sex and the odds ratio (OR) of recurrence were pooled using a random-effects model. RESULTS: Outcome data were analyzed for 20,336 tumors from 34 studies. We found different proportions of highgrade meningiomas in the brain (12.8%) (95% confidence interval [CI], 10.5%-15.1%) versus the spine (2.4%) (95% CI, 1.0%-3.7%) (P < 0.01). Skull base meningiomas (8.7%) (95% CI, 5.8%-11.6%) had a lower proportion of high-grade meningiomas than non-skull base meningiomas (16.5%) (95% CI, 11.9%-21.1%) (P < 0.01). In addition, high-grade meningiomas were more likely to occur in male patients (18.0%) (95% CI, 10.1%-25.9%) than female patients (7.0%) (95% CI, 3.5%-10.6%) (P = 0.01). Higher rates of recurrence (OR = 13.83) were confirmed for high-grade men ingiomas than grade I meningiomas (95% CI, 4.10-46.65) (P < 0.01). CONCLUSIONS: This meta-analysis found that intracran ial, nonskull base, and male sex are risk factors for high grade meningioma, and high-grade meningioma had a much higher recurrence rate as compared with grade I meningioma.
- 신홍경; 박진훈; 조영현; 김영훈; 홍석호; 김정훈; 노성우; 전상용
- Issued Date
- High-grade meningioma; Meta-analysis; Recurrence; Risk factor.
- WORLD NEUROSURGERY
- Citation Volume
- Citation Start Page
- Citation End Page
Appears in Collections:
- Medicine > Medicine
- Authorize & License
- Files in This Item:
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.