KLI

Serum Peptide Immunoglobulin G Autoantibody Response in Patients with Different Central Nervous System Inflammatory Demyelinating Disorders

Metadata Downloads
Abstract
Previous efforts to discover new surrogate markers for the central nervous system (CNS) inflammatory demyelinating disorders have shown inconsistent results; moreover, supporting evidence is scarce. The present study investigated the IgG autoantibody responses to various viral and autoantibodies-related peptides proposed to be related to CNS inflammatory demyelinating disorders using the peptide microarray method. We customized a peptide microarray containing more than 2440 immobilized peptides representing human and viral autoantigens. Using this, we tested the sera of patients with neuromyelitis optica spectrum disorders (NMOSD seropositive, n = 6; NMOSD seronegative, n = 5), multiple sclerosis (MS, n = 5), and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD, n = 6), as well as healthy controls (HC, n = 5) and compared various peptide immunoglobulin G (IgG) responses between the groups. Among the statistically significant peptides based on the pairwise comparisons of IgG responses in each disease group to HC, cytomegalovirus (CMV)-related peptides were most clearly distinguishable among the study groups. In particular, the most significant differences in IgG response were observed for HC vs. MS and HC vs. seronegative NMOSD (p = 0.064). Relatively higher IgG responses to CMV-related peptides were observed in patients with MS and NMOSD based on analysis of the customized peptide microarray.
Author(s)
강사윤권오현김병조김병조김병준김병준김호진민주홍박진우석진명석형열신하영이상수이성현이혜림임영민전미영
Issued Date
2021
Type
Article
Keyword
AntibodiesAntigensCNS inflammatory demyelinating disorderCytomegalovirusDiseaseEpstein-Barr virusGlycoproteinslgG responseLaboratoriespeptide microarrayPeptidesStatistical analysisVariance analysis
DOI
10.3390/diagnostics11081339
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8344
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_cd024cfe42e543f8a5bfc82103b1ef6e&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Serum%20Peptide%20Immunoglobulin%20G%20Autoantibody%20Response%20in%20Patients%20with%20Different%20Central%20Nervous%20System%20Inflammatory%20Demyelinating%20Disorders&offset=0&pcAvailability=true
Publisher
DIAGNOSTICS
Location
스위스
Language
한국어
ISSN
2075-4418
Citation Volume
11
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
공개 및 라이선스
  • 공개 구분공개
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.