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Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension

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Abstract
Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs) results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous afflictions is crucial for glaucoma treatment. In this study, we aimed to investigate the beneficial effects of statins in the protection of RGCs using a rat model. Glaucomatous injury was induced in rats by chronic ocular hypertension (OHT) achieved after performing a circumlimbal suture. The rats were given either statins such as simvastatin and atorvastatin or a solvent weekly for 6 weeks. Retina sections underwent hematoxylin and eosin, Brn3a, or cleaved casepase-3 staining to evaluate RGC survival. In addition, modulation of glial activation was assessed. While the retinas without statin treatment exhibited increased RGC death due to chronic OHT, statins promoted the survival of RGCs and reduced apoptosis. Statins also suppressed chronic OHT-mediated glial activation in the retina. Our results demonstrate that statins exert neuroprotective effects in rat retinas exposed to chronic OHT, which may support the prospect of statins being a glaucoma treatment.
Author(s)
김미량성경림권준기최고운신진아
Issued Date
2021
Type
Article
Keyword
retinal ganglion cell statin glaucoma neuroprotection ocular hypertension
DOI
10.3390/ijms222212500
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8347
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_c4801c941ff54baea351cff86f4deb7e&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Neuroprotective%20Effect%20of%20Statins%20in%20a%20Rat%20Model%20of%20Chronic%20Ocular%20Hypertension&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Location
미국
Language
영어
ISSN
1422-0067
Citation Volume
22
Citation Number
22
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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