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Real-world Experience of Improvement in the Survival of Lymphoma and Myeloma Patients with Autologous Stem Cell Transplantation over a 25-year Period

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Abstract
Abstract
Background/Aims
The first autologous peripheral blood stem cell transplantation (ASCT) in Korea was performed for a small-cell lung cancer patient at Asan Medical Center (AMC) in 1993. Recently, lymphoma and myeloma have been the main indications; there has been progress in the treatments for these lymphoid malignancies. We explored the real-world experience of ASCT for lymphoma and myeloma at AMC over a 25-year period.
Methods
We used the AMC ASCT registry, which has collected ASCT data prospectively since January 1993. Data for Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma patients were analyzed. Patients transplanted up to December 2018 were included to assess adequate survival data. The ASCT time period was divided arbitrarily into 1994-1999, 2000-2009, and 2010-2018. In cases of multiple myeloma, we analyzed the 1st ASCT data only.
Results
Survival of these lymphoid malignancy patients after ASCT has progressively improved. The increase in survival may be related to advances in various medical skills supporting ASCT. However, overall survival has improved much more than progression-free survival. This suggests that better salvage therapies after ASCT failure have mainly affected the improvement in overall survival. The hematopoietic cell transplantation-specific comorbidity index could not be used as a survival indicator in this analysis.
Conclusions
This real-world experience study showed that the survival of lymphoid malignancy patients treated with ASCT has improved over the past 25 years.
Author(s)
김신박정선서철원이경민조형우
Issued Date
2021
Type
Article
Keyword
AutologousPeipheral blood stem cell transplantationLymphomaMultiple myelomaComorbidity
DOI
10.3904/kjm.2021.96.6.501
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8349
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_3904_kjm_2021_96_6_501&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Real-world%20Experience%20of%20Improvement%20in%20the%20Survival%20of%20Lymphoma%20and%20Myeloma%20Patients%20with%20Autologous%20Stem%20Cell%20Transplantation%20over%20a%2025-year%20Period&offset=0&pcAvailability=true
Publisher
대한내과학회지
Location
대한민국
Language
영어
ISSN
1738-9364
Citation Volume
96
Citation Number
6
Citation Start Page
501
Citation End Page
511
Appears in Collections:
Medicine > Medicine
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