KLI

Kinetics of the neutrophil-lymphocyte ratio during PD-1 inhibition as a prognostic factor in advanced hepatocellular carcinoma

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Abstract
Background and Aims Programmed death 1 (PD-1) inhibitors have improved survival outcomes and produced durable responses in advanced hepatocellular carcinoma (HCC) for some patients. Here, we evaluated the relationship between the baseline and kinetics of the neutrophil-lymphocyte ratio (NLR) and clinical outcomes in nivolumab-treated HCC patients.

Methods All consecutive HCC patients treated with nivolumab between July 2017 and June 2020 were screened for the eligibility. The NLRs were calculated before and at 2, 4 and 6 weeks after treatment. Survival outcomes were compared based on the baseline and kinetics of NLR. We additionally analysed the association of the baseline and dynamic changes in the NLR with hyperprogression (HPD).

Results Among the 194 included cases, most patients were male (82.0%) and had a Child-Pugh Class A disease (70.6%). Patients with a baseline NLR >= 3 (hazard ratio [HR] 2.46; 95% CI 1.63-3.71) had a poorer overall survival than patients with baseline NLR < 3. During the treatment, the NLR increased rapidly in patients developing HPD, and only a Delta NLR at 4 weeks was predictive of HPD. The risk of HPD increased by 20% for every 20% increase in the Delta NLR at 4 weeks. Accordingly, an NLR increase at 4 weeks (HR 1.79; 95% CI 1.19-2.68) was associated with an increased risk of death, especially among patients with a baseline NLR >= 3.

Conclusions The baseline and on-treatment kinetics for the NLR are effective prognostic indicators in nivolumab-treated patients with HCC. This may help to guide patient selection and on-treatment strategies for immunotherapies in advanced HCC.
Author(s)
김강모김지윤류백렬심주현유민희유창훈이단비이한주임영석최원묵최종기
Issued Date
2021
Type
Article
Keyword
dynamic changesHepatomahyperprogressionimmune checkpoint inhibitorImmunotherapyLiverliver cancerLymphocytesPrognosis
DOI
10.1111/liv.14932
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8358
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2524867704&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Kinetics%20of%20the%20neutrophil-lymphocyte%20ratio%20during%20PD-1%20inhibition%20as%20a%20prognostic%20factor%20in%20advanced%20hepatocellular%20carcinoma&amp;offset=0&amp;pcAvailability=true
Publisher
LIVER INTERNATIONAL
Location
미국
Language
한국어
ISSN
1478-3223
Citation Volume
41
Citation Number
9
Citation Start Page
2189
Citation End Page
2199
Appears in Collections:
Medicine > Medicine
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