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Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia

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Abstract
Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0-122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3-4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.
Author(s)
강가원강혜진고영일고영혜곽재용권정혜김원석김진석김효정도영록문영철박성규손병석심혜옥오성용윤덕현윤상은윤환중이원식이호섭이홍표조재철한재준Cosphiadi IrawanDaryl Tan Chen LungKevin Tay Kuang WeiMark Hong LeeMichelle PoonSoo Chin NgSoon Thye LimTsai-Yun ChenWeili ZhaoYe
Issued Date
2021
Type
Article
Keyword
CutaneousIncidenceLymphomaPrognosisSurvivalT-cellTherapeutics.
DOI
10.1007/s12185-021-03179-7
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8360
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A671901029&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Cutaneous%20T-cell%20lymphoma%20in%20Asian%20patients:%20a%20multinational,%20multicenter,%20prospective%20registry%20study%20in%20Asia&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF HEMATOLOGY
Location
일본
Language
영어
ISSN
0925-5710
Citation Volume
114
Citation Number
3
Citation Start Page
355
Citation End Page
362
Appears in Collections:
Medicine > Medicine
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