Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia
- Abstract
- Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0-122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3-4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.
- Author(s)
- 강가원; 강혜진; 고영일; 고영혜; 곽재용; 권정혜; 김원석; 김진석; 김효정; 도영록; 문영철; 박성규; 손병석; 심혜옥; 오성용; 윤덕현; 윤상은; 윤환중; 이원식; 이호섭; 이홍표; 조재철; 한재준; Cosphiadi Irawan; Daryl Tan Chen Lung; Kevin Tay Kuang Wei; Mark Hong Lee; Michelle Poon; Soo Chin Ng; Soon Thye Lim; Tsai-Yun Chen; Weili Zhao; Ye
- Issued Date
- 2021
- Type
- Article
- Keyword
- Cutaneous; Incidence; Lymphoma; Prognosis; Survival; T-cell; Therapeutics.
- DOI
- 10.1007/s12185-021-03179-7
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8360
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A671901029&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Cutaneous%20T-cell%20lymphoma%20in%20Asian%20patients:%20a%20multinational,%20multicenter,%20prospective%20registry%20study%20in%20Asia&offset=0&pcAvailability=true
- Publisher
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Location
- 일본
- Language
- 영어
- ISSN
- 0925-5710
- Citation Volume
- 114
- Citation Number
- 3
- Citation Start Page
- 355
- Citation End Page
- 362
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- Medicine > Medicine
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