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Anaphylaxis to tocilizumab in patients with rheumatic disease

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Abstract
Abstract


Background: Anaphylaxis to tocilizumab has been reported anecdotally. Therefore, we evaluated the incidence of anaphylaxis in patients starting tocilizumab. Materials & methods: This retrospective study included patients with rheumatic disease who were administered tocilizumab from 2013 to 2020. The incidence of anaphylaxis was examined during the first 6 months. Results: During follow-up, four of 171 patients developed anaphylaxis within the third course of infusions. The incidence of anaphylaxis to tocilizumab was higher in patients with adult-onset Still's disease (AOSD) than in those with other rheumatic disease (21.4% in AOSD vs 0.7% in rheumatoid arthritis vs 0% in Takayasu arteritis). Conclusions: When we consider tocilizumab treatment, especially in AOSD, we should keep in mind that intensive monitoring for anaphylaxis is necessary.
Author(s)
권혁수김용길김태범남소혜안수민오지선유빈이창근임두호허현미홍석찬
Issued Date
2021
Type
Article
Keyword
adult-onset Still's diseaseanaphylaxisrheumatoid arthritisTakayasu arteritistocilizumab
DOI
10.2217/imt-2020-0307
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8381
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_2217_imt_2020_0307&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Anaphylaxis%20to%20tocilizumab%20in%20patients%20with%20rheumatic%20disease&offset=0&pcAvailability=true
Publisher
Immunotherapy
Location
영국
Language
한국어
ISSN
1750-743X
Citation Volume
13
Citation Number
18
Citation Start Page
1483
Citation End Page
1489
Appears in Collections:
Medicine > Medicine
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