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Correlation between Reactogenicity and Immunogenicity after the ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccination

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Abstract
Correlation between vaccine reactogenicity and immunogenicity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Thus, we investigated to determine whether the reactogenicity after coronavirus disease 2019 vaccination is associated with Ab titers and T cell responses. This study was prospective cohort study done with 131 healthcare workers at tertiary center in Seoul, South Korea. The degrees of the local reactions after the 1st and 2nd doses of ChAdOx1 vaccination were significantly associated with the S1-specific IgG Ab titers (p=0.003 and 0.01, respectively) and neutralizing Ab (p=0.04 and 0.10, respectively) in age- and sex-adjusted multivariate analysis, whereas those after the BNT162b2 vaccination did not show significant associations. T cell responses did not show significant associations with the degree of reactogenicity after the ChAdOx1 vaccination or the BNT162b2 vaccination. Thus, high degree of local reactogenicity after the ChAdOx1 vaccine may be used as an indicator of strong humoral immune responses against SARS-CoV-2.
Author(s)
권지수김기덕김성한김지연데이비드샴박순주박지영배성만서미현이낙영이현정임소윤임준서정지원지영미차혜희
Issued Date
2021
Type
Article
Keyword
COVID-19vaccineAntibody responseNeutralizing antibodyInjection site reaction
DOI
10.4110/in.2021.21.e41
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8382
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9906655&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Correlation%20between%20Reactogenicity%20and%20Immunogenicity%20after%20the%20ChAdOx1%20nCoV-19%20and%20BNT162b2%20mRNA%20Vaccination&offset=0&pcAvailability=true
Publisher
IMMUNE NETWORK
Location
대한민국
Language
한국어
ISSN
1598-2629
Citation Volume
21
Citation Number
6
Citation Start Page
43
Citation End Page
43
Appears in Collections:
Medicine > Medicine
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