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Invasive Mucormycosis Involving the Laryngopharynx After Bone Marrow Transplantation

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Alternative Title
Invasive Mucormycosis Involving the Laryngopharynx After Bone Marrow Transplantation
Abstract
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Invasive larynx or pharyngeal fungal infections are rare. We report an invasive fungal laryngopharyngitis patient who complained of a persistent sore throat after an allogenic bone marrow transplant and a haploidentical stem cell transplant. An antifungal gargle was used after finding necrotic changes extending from the right soft palate to the aryepiglottic fold. Biopsy and culture suggested a fungal infection with suspicious mucormycosis. Imaging showed the right oropharynx, supraglottis, and the parapharnygeal space were involved. After initiating liposomal amphotericin B for 4 days, wide excisional debridement, and a partial pharyngectomy with an anterolateral thigh free flap including the deep fascia were performed. Amphotericin B and posaconazole were used subsequently. Pathology assessment indicated invasive mucormycosis. There was no recurrence for 9 months. Mucormycosis is a fatal opportunistic infection often seen in immunocompromised patients. Rapid detection, radical resection, and reconstruction can save the patient from a life-threatening fungal infection of the laryngopharynx.
Author(s)
이영주이윤세
Issued Date
2021
Type
Article
Keyword
Flap reconstructioninvasive fungal infectionmucormycosissurgerytreatment
DOI
10.1097/SCS.0000000000008167
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8384
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2574743412&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Invasive%20Mucormycosis%20Involving%20the%20Laryngopharynx%20After%20Bone%20Marrow%20Transplantation&offset=0&pcAvailability=true
Publisher
JOURNAL OF CRANIOFACIAL SURGERY
Location
미국
Language
한국어
ISSN
1049-2275
Citation Volume
1
Citation Number
1
Citation Start Page
1
Citation End Page
1
Appears in Collections:
Medicine > Medicine
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