KLI

Acute Promyelocytic Leukemia with a BCR-ABL1 Rearrangement in a Minor Clone

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Abstract
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Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia characterized by predominating abnormal promyelocytes with a PML-RARA rearrangement or a variant thereof. BCR-ABL1 rearrangement is an oncogenic event that is usually associated with chronic myeloid leukemia but also occurs in both acute lymphoblastic and acute myeloid leukemias and in healthy individuals. However, APL with concurrent PML-RARA and BCR-ABL1 rearrangements has rarely been reported. Herein, we describe a patient with APL exhibiting a BCR-ABL1 rearrangement in a minor clone and discuss the importance of evaluating this genetic alteration in terms of pathogenesis and treatment.
Author(s)
김미영Boram HanJungwon HyunYonggeun ChoYoung Kyung Lee
Issued Date
2021
Type
Article
Keyword
acute promyelocytic leukemia BCR-ABL1 PML-RARA concurrent minor clone treatment
DOI
10.1093/labmed/lmab097
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8391
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2592311149&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Acute%20Promyelocytic%20Leukemia%20with%20a%20BCR-ABL1%20Rearrangement%20in%20a%20Minor%20Clone&offset=0&pcAvailability=true
Publisher
Laboratory Medicine
Location
미국
Language
영어
ISSN
0007-5027
Citation Volume
1
Citation Number
1
Citation Start Page
lmab097
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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