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Role of the prognostic nutritional index in predicting survival in advanced hepatocellular carcinoma treated with regorafenib

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Abstract
Aim A link has been established between malnutrition, immunological status, and hepatocellular carcinoma (HCC). The prognostic nutritional index (PNI) has been recognized as a prognostic indicator in early-stage HCC and in patients treated with first-line therapy. However, to date, the role of the PNI in HCC patients treated with regorafenib has not been reported.

Methods We undertook a multicentric analysis on a cohort of 284 patients affected by advanced HCC treated with regorafenib. The PNI was calculated as follows: 10 x serum albumin concentration (g/dl) + 0.005 x peripheral lymphocyte count (number/mm(3)). Univariate and multivariate analyses were used to investigate the association between PNI and survival outcomes.

Results A PNI cut-off value of 44.45 was calculated by a receiver operating characteristic analysis. The median overall survival was 12.8 and 7.8 months for patients with high (>44.45) and low (<= 44.45) PNI, respectively (hazard ratio, 0.58; 95% confidence interval, 0.43-0.77; p = 0.0002). In the univariate and multivariate analyses, low PNI value and increased serum bilirubin level emerged as independent prognostic factors for overall survival. No differences were found between high and low PNI in terms of progression-free survival (p = 0.14).

Conclusion If validated, the PNI could represent an easy-to-use prognostic tool able to guide the clinical decision-making process in HCC patients treated with regorafenib.
Author(s)
김형돈류백렬방영학유민희유창훈Alessandro CucchettiAndrea Casadei-GardiniAntonella ForgioneCaterina SoldaFabio PiscagliaFrancesca SalaniGianluca MasiLuca IelasiMargherita RiminiMario D RizzatoSara LonardiSilvia CataneseStefano CascinuValentina BurgioVito Sansone
Issued Date
2021
Type
Article
Keyword
atezolizumabcabozantinibregorafenibsorafenib.
DOI
10.1111/hepr.13669
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8417
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2528910739&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Role%20of%20the%20prognostic%20nutritional%20index%20in%20predicting%20survival%20in%20advanced%20hepatocellular%20carcinoma%20treated%20with%20regorafenib&amp;offset=0&amp;pcAvailability=true
Publisher
HEPATOLOGY RESEARCH
Location
미국
Language
한국어
ISSN
1386-6346
Citation Volume
51
Citation Number
7
Citation Start Page
796
Citation End Page
802
Appears in Collections:
Medicine > Medicine
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