Role of the prognostic nutritional index in predicting survival in advanced hepatocellular carcinoma treated with regorafenib
- Abstract
- Aim A link has been established between malnutrition, immunological status, and hepatocellular carcinoma (HCC). The prognostic nutritional index (PNI) has been recognized as a prognostic indicator in early-stage HCC and in patients treated with first-line therapy. However, to date, the role of the PNI in HCC patients treated with regorafenib has not been reported.
Methods We undertook a multicentric analysis on a cohort of 284 patients affected by advanced HCC treated with regorafenib. The PNI was calculated as follows: 10 x serum albumin concentration (g/dl) + 0.005 x peripheral lymphocyte count (number/mm(3)). Univariate and multivariate analyses were used to investigate the association between PNI and survival outcomes.
Results A PNI cut-off value of 44.45 was calculated by a receiver operating characteristic analysis. The median overall survival was 12.8 and 7.8 months for patients with high (>44.45) and low (<= 44.45) PNI, respectively (hazard ratio, 0.58; 95% confidence interval, 0.43-0.77; p = 0.0002). In the univariate and multivariate analyses, low PNI value and increased serum bilirubin level emerged as independent prognostic factors for overall survival. No differences were found between high and low PNI in terms of progression-free survival (p = 0.14).
Conclusion If validated, the PNI could represent an easy-to-use prognostic tool able to guide the clinical decision-making process in HCC patients treated with regorafenib.
- Author(s)
- 김형돈; 류백렬; 방영학; 유민희; 유창훈; Alessandro Cucchetti; Andrea Casadei-Gardini; Antonella Forgione; Caterina Solda; Fabio Piscaglia; Francesca Salani; Gianluca Masi; Luca Ielasi; Margherita Rimini; Mario D Rizzato; Sara Lonardi; Silvia Catanese; Stefano Cascinu; Valentina Burgio; Vito Sansone
- Issued Date
- 2021
- Type
- Article
- Keyword
- atezolizumab; cabozantinib; regorafenib; sorafenib.
- DOI
- 10.1111/hepr.13669
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8417
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2528910739&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Role%20of%20the%20prognostic%20nutritional%20index%20in%20predicting%20survival%20in%20advanced%20hepatocellular%20carcinoma%20treated%20with%20regorafenib&offset=0&pcAvailability=true
- Publisher
- HEPATOLOGY RESEARCH
- Location
- 미국
- Language
- 한국어
- ISSN
- 1386-6346
- Citation Volume
- 51
- Citation Number
- 7
- Citation Start Page
- 796
- Citation End Page
- 802
-
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