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Value of 18F-FDG PET in Neuroendocrine Neoplasm: A Systematic Review and Meta-analysis

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Abstract
Abstract
Objectives: Accurate assessment of the prognosis is critical for the rational treatment of neuroendocrine neoplasms (NENs). We performed a systematic review and meta-analysis of the prognostic value of 18F-FDG PET for NENs.

Patients and methods: PubMed and Embase databases were searched up to September 2020 for studies that evaluated 18F-FDG PET as prognostic factors in patients with NENs with overall survival (OS) and event-free survival (EFS) as outcomes. Hazards ratios (HRs) comparing high and low FDG uptakes were pooled using the DerSimonian-Laird method. Publication bias was assessed and adjusted for using the trim-and-fill method. Metaregression and subgroup analyses were performed to explore the cause of heterogeneity.

Results: Twenty-three studies (1799 patients) were included. The overall pooled HRs of high FDG uptake on EFS and OS were 2.84 (95% confidence interval [CI], 2.21-3.64) and 3.50 (95% CI, 2.42-4.12), respectively. Publication biases were present regarding both EFS and OS (P = 0.0342 and 0.0009, respectively). After adjustment, effect sizes remained significant for EFS and OS (adjusted HR, 2.26 [95% CI, 1.76-2.89]; 3.16 [95% CI, 2.42-4.12]). In metaregression analyses, the proportion of grade 3 tumors positively correlated with the HR of OS (adjusted P = 0.0422).

Conclusions: 18F-FDG PET is a significant prognostic factor in patients with NENs. 18F-FDG PET might be a useful prognostic biomarker in conjunction with the histologic grade and can help select the optimal treatment.
Author(s)
김태형류백렬류진숙우성민유창훈이효상한상원
Issued Date
2021
Type
Article
Keyword
2021A02043과 중복논문으로 반려
DOI
10.1097/RLU.0000000000003682
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8418
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2531533453&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Value%20of%2018F-FDG%20PET%20in%20Neuroendocrine%20Neoplasm:%20A%20Systematic%20Review%20and%20Meta-analysis&offset=0&pcAvailability=true
Publisher
CLINICAL NUCLEAR MEDICINE
Location
미국
Language
영어
ISSN
0363-9762
Citation Volume
46
Citation Number
9
Citation Start Page
723
Citation End Page
731
Appears in Collections:
Medicine > Medicine
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