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Olaparib with or without bevacizumab or bevacizumab and 5-fluorouracil in advanced colorectal cancer: Phase III LYNK-003

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Abstract
Oxaliplatin-based chemotherapy with a regimen such as FOLFOX with or without targeted therapy is a standard of care option for advanced colorectal cancer; however, long-term exposure to oxaliplatin is associated with cumulative toxicity. Growing evidence suggests maintenance therapy with a less intensive regimen after platinum-based induction therapy can provide continuing benefit with reduced toxicity. We describe the rationale and design of the Phase III LYNK-003 trial, which will evaluate the efficacy and safety of olaparib with or without bevacizumab compared with 5-fluoruracil plus bevacizumab in patients with unresectable or metastatic colorectal cancer that has not progressed on an induction course of FOLFOX plus bevacizumab. The primary end point is progression-free survival by independent central review; secondary end points include overall survival, objective response, duration of response and safety.
Author(s)
김태원Ellen B GuraryJulien TaiebKaren CuiNati LermanTakayuki Yoshino
Issued Date
2021
Type
Article
Keyword
5-fluorouracilbevacizumabcolorectal cancerFOLFOXfolinic acidirinotecanmaintenace therapyolapariboxaliplatinPARP inhibitor
DOI
10.2217/fon-2021-0899
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8482
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_2217_fon_2021_0899&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Olaparib%20with%20or%20without%20bevacizumab%20or%20bevacizumab%20and%205-fluorouracil%20in%20advanced%20colorectal%20cancer:%20Phase%20III%20LYNK-003&offset=0&pcAvailability=true
Publisher
Future Oncology
Location
영국
Language
한국어
ISSN
1479-6694
Citation Volume
17
Citation Number
36
Citation Start Page
5013
Citation End Page
5022
Appears in Collections:
Medicine > Medicine
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