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The mean of fasting, 1-h, and 2-h plasma glucoselevels is superior to each separate index inpredicting diabetes

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Abstract
Aims
The fasting, 1-h, and 2-h plasma glucose (PG) levels during oral glucose tolerance test represent different glucose metabolic functions. We examined whether averaging these PG indices (GLUM0.60.120) results in a better predictor of future type 2 diabetes (T2DM).

Methods
7533 participants were followed up biannually for 12 years. Hazard ratios (HRs), area under the curve (AUC) of the receiver-operating characteristic, and the net reclassification index (NRI) for T2DM were calculated to compare the discriminative ability of GLUM0.60.120 versus other PG indices.

Results
The adjusted HRs and 95% confidence intervals for an increase in SD of GLUM0.60.120 was 2.50 (2.36?2.65) and 1.88 (1.73?2.04) in T2DM-free and normal glucose tolerance (NGT) participants, respectively. The AUC of GLUM0.60.120 was higher than that of fasting PG, 1-h, and 2-h PG values for T2DM-free (0.79 versus 0.67, 0.77, and 0.73) and NGT (0.73 versus 0.65, 0.72, and 0.61). The model using GLUM0.60.120 improved the classification of the models with fasting PG, 1-h, and 2-h PG values (NRI: 0.369, 0.272, and 0.282 for T2DM-free and 0.249, 0.131, and 0.351 for NGT participants with all p < 0.001).

Conclusions
The mean of fasting, 1-h, and 2-h PG levels predicts future T2DM better than each index.
Author(s)
이영선전윤완최선옥팜둑두옹임채헌
Issued Date
2021
Type
Article
Keyword
1-h PG2-h PGAnalysisAveragingBlood Glucose - metabolismDextroseType 2 - bloodFastingFasting - bloodFemaleFPGGlucoseGlucose metabolismGlucose tolerance testsHumansMaleMedical collegesMiddle AgedOGTTType 2 diabetes
DOI
10.1016/j.diabres.2021.108650
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8498
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2476851623&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,The%20mean%20of%20fasting,%201-h,%20and%202-h%20plasma%20glucoselevels%20is%20superior%20to%20each%20separate%20index%20inpredicting%20diabetes&amp;offset=0&amp;pcAvailability=true
Publisher
DIABETES RESEARCH AND CLINICAL PRACTICE
Location
미국
Language
영어
ISSN
0168-8227
Citation Volume
172
Citation Number
0
Citation Start Page
108650
Citation End Page
108650
Appears in Collections:
Medicine > Medicine
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