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Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults

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Abstract
Long-term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients who underwent cochlear implantation and 37 patients who were MRI-scanned within 2 weeks after the onset of sudden hearing loss and expected with minimal brain structural changes in relation to deafness. Compared with those with sudden hearing loss, we found lower gray matter (GM) probabilities in bilateral thalami, superior, middle, inferior temporal cortices as well as the central cortical regions corresponding to the movement and sensation of the lips, tongue, and larynx in the PD group. Among these brain areas, the GM in the middle temporal cortex showed negative correlation with disease duration, whereas the other areas displayed positive correlations. Left superior, middle temporal cortical, and bilateral thalamic GMs were the most accurate predictors of post-cochlear implantation word recognition scores (mean absolute error [MAE] = 10.1, r =.82), which was superior to clinical variables used (MAE: 12.1, p <.05). Using the combined brain morphological and clinical features, we achieved the best prediction of the outcome (MAE: 8.51, r =.90). Our findings suggest that the cross-modal plasticity allowing the superior temporal cortex and thalamus to process other modal sensory inputs reverses the initially lower volume when deafness becomes persistent. The middle temporal cortex processing higher-level language comprehension shows persistent negative correlations with disease duration, suggesting this area's association with degraded speech comprehensions due to long-term deafness. Morphological features combined with clinical variables might play a key role in predicting outcomes of cochlear implantation.
Author(s)
강우석곽민영김예리박준우박홍주서지원안중호이제연이지연정종우Hosung KimZhe Sun
Issued Date
2021
Type
Article
Keyword
cochlear implanthearing lossplasticityprognosisvoxel-based morphometry.
DOI
10.1002/hbm.25219
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8507
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2449178617&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Cortical%20reorganization%20following%20auditory%20deprivation%20predicts%20cochlear%20implant%20performance%20in%20postlingually%20deaf%20adults&amp;offset=0&amp;pcAvailability=true
Publisher
HUMAN BRAIN MAPPING
Location
미국
Language
영어
ISSN
1065-9471
Citation Volume
42
Citation Number
1
Citation Start Page
233
Citation End Page
244
Appears in Collections:
Medicine > Medicine
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