KLI

Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children through Leptin and Interleukin-1 beta

Metadata Downloads
Abstract
Background: Obesity/overweight is associated with a higher risk of allergic rhinitis (AR) in children. Objective: This study aimed at exploring the mechanisms by which obesity affects the severity of AR through leptin and interleukin (IL)-1 beta were investigated. Methods: In all, 210 subjects with AR and 82 subjects without AR were included in this study. The levels of leptin and inflammatory biomarkers were measured in the serum to investigate the correlation with the severity of AR. Additionally, we analyzed whether changes in BMI regulate the severity of AR through serial follow-up of obese children. Results: IL-1 beta, which is a biomarker of active inflammation in AR, was significantly higher in individuals with AR than in those without and higher in subjects in the obesity group than in those in the normal weight group. A regression analysis showed that the leptin level was associated with increased IL-1 beta expression in children with AR. In the multivariate analysis, only parental AR (9.2-fold increase in risk), elevated leptin (11.3-fold increase in risk), and high expression of IL-1 beta (5.8-fold increase in risk) emerged as significant risk factors of moderate to severe persistent allergic rhinitis. We also found that children with an increase or decrease in BMI showed changes in IL-1 beta and AR symptoms, which these changes were dependent on leptin and BMI. Conclusions: These results suggest that obesity is an important risk factor for the exacerbation of symptoms and leptin can exacerbate inflammation as well as severe and persistent symptoms through IL-1 beta in AR.
Author(s)
김송희김양호오인보이지호한명월
Issued Date
2021
Type
Article
Keyword
Allergic rhinitis · Obesity · Interleukin-1β · Leptin · BMI
DOI
10.1159/000512920
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8508
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1159_000512920&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Obesity%20Can%20Contribute%20to%20Severe%20Persistent%20Allergic%20Rhinitis%20in%20Children%20through%20Leptin%20and%20Interleukin-1%20beta&offset=0&pcAvailability=true
Publisher
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Location
스웨덴
Language
영어
ISSN
1018-2438
Citation Volume
182
Citation Number
6
Citation Start Page
546
Citation End Page
552
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.