Technical Feasibility and Histological Analysis of Balloon-Expandable Metallic Stent Placement in a Porcine Eustachian Tube
- Abstract
- There is a clinical need to develop a stent to treat obstructive and refractory Eustachian
tube dysfunction (ETD) after balloon Eustachian tuboplasty. An animal model for stent placement
in the Eustachian tube (ET) is needed to develop optimal designs and materials, as stents for ETD
have not been clinically applied. The purpose of this study was to evaluate the technical feasibility
of stent placement and histological changes in a porcine ET model. Six ETs were evaluated in three
pigs. Cobalt?chrome alloy stents with two different diameters were placed in the left and right
ET of each animal (right, 3.5 mm; left, 2.5 mm). The outcomes were assessed by endoscopic and
fluoroscopic imaging during the procedure, computed tomography after the procedure, and by
histological examinations. Stent placement was technically successful in all specimens after metallic
guiding sheaths were located in the nasopharyngeal end of the ET. The mean luminal diameters of the
proximal, middle, and distal portions of the larger stents in the right ETs were 3.48 mm, 2.54 mm, and
2.15 mm, respectively. In the left ETs using smaller stents, these values were 2.49 mm, 1.73 mm, and
1.42 mm, respectively. The diameters of the inserted stents differed by stent location and the original
diameter. Histological findings showed tissue hyperplasia with severe inflammatory cell infiltration
at 4 weeks after stent placement. In conclusion, stent placement into the porcine ET was technically
feasible, and stent-induced tissue hyperplasia was significantly evident. The luminal configuration
of the placed ET stent changed according to its non-elastic nature and anatomical features of the
porcine ET. Using this model, ET stents of various materials and designs with anti-inflammatory or
anti-proliferative drugs can be optimized for future treatments of ET dysfunction.
- Author(s)
- 강우석; 곽민영; 김예리; 박정훈; 박홍주; Dae Sung Ryu; Dae Sung Ryu; Jeon Min Kang
- Issued Date
- 2021
- Type
- Article
- Keyword
- Eustachian tube; stent; Eustachian tube dysfunction; tissue hyperplasia; otitis media
- DOI
- 10.3390/app11041359
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8509
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_0c1b01e213944fb1838bf49690091388&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Technical%20Feasibility%20and%20Histological%20Analysis%20of%20Balloon-Expandable%20Metallic%20Stent%20Placement%20in%20a%20Porcine%20Eustachian%20Tube&offset=0&pcAvailability=true
- Publisher
- APPLIED SCIENCES-BASEL
- Location
- 스위스
- Language
- 영어
- ISSN
- 2076-3417
- Citation Volume
- 11
- Citation Number
- 4
- Citation Start Page
- 1359
- Citation End Page
- 1359
-
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