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Technical Feasibility and Histological Analysis of Balloon-Expandable Metallic Stent Placement in a Porcine Eustachian Tube

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Abstract
There is a clinical need to develop a stent to treat obstructive and refractory Eustachian
tube dysfunction (ETD) after balloon Eustachian tuboplasty. An animal model for stent placement
in the Eustachian tube (ET) is needed to develop optimal designs and materials, as stents for ETD
have not been clinically applied. The purpose of this study was to evaluate the technical feasibility
of stent placement and histological changes in a porcine ET model. Six ETs were evaluated in three
pigs. Cobalt?chrome alloy stents with two different diameters were placed in the left and right
ET of each animal (right, 3.5 mm; left, 2.5 mm). The outcomes were assessed by endoscopic and
fluoroscopic imaging during the procedure, computed tomography after the procedure, and by
histological examinations. Stent placement was technically successful in all specimens after metallic
guiding sheaths were located in the nasopharyngeal end of the ET. The mean luminal diameters of the
proximal, middle, and distal portions of the larger stents in the right ETs were 3.48 mm, 2.54 mm, and
2.15 mm, respectively. In the left ETs using smaller stents, these values were 2.49 mm, 1.73 mm, and
1.42 mm, respectively. The diameters of the inserted stents differed by stent location and the original
diameter. Histological findings showed tissue hyperplasia with severe inflammatory cell infiltration
at 4 weeks after stent placement. In conclusion, stent placement into the porcine ET was technically
feasible, and stent-induced tissue hyperplasia was significantly evident. The luminal configuration
of the placed ET stent changed according to its non-elastic nature and anatomical features of the
porcine ET. Using this model, ET stents of various materials and designs with anti-inflammatory or
anti-proliferative drugs can be optimized for future treatments of ET dysfunction.
Author(s)
강우석곽민영김예리박정훈박홍주Dae Sung RyuDae Sung RyuJeon Min Kang
Issued Date
2021
Type
Article
Keyword
Eustachian tubestentEustachian tube dysfunctiontissue hyperplasiaotitis media
DOI
10.3390/app11041359
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8509
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_0c1b01e213944fb1838bf49690091388&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Technical%20Feasibility%20and%20Histological%20Analysis%20of%20Balloon-Expandable%20Metallic%20Stent%20Placement%20in%20a%20Porcine%20Eustachian%20Tube&offset=0&pcAvailability=true
Publisher
APPLIED SCIENCES-BASEL
Location
스위스
Language
영어
ISSN
2076-3417
Citation Volume
11
Citation Number
4
Citation Start Page
1359
Citation End Page
1359
Appears in Collections:
Medicine > Medicine
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