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A Prospective Study on the Association between Oxidative Stress and Duration of Symptoms in Allergic Rhinitis

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Abstract
Oxidative stress has been known to play an important role in inflammatory responses of allergic rhinitis. We investigated the association between degree of oxidative stress and severity of allergic rhinitis. A total 226 allergic rhinitis students were classified by a history of allergic rhinitis into groups according to number and duration of symptoms within the previous year. The total antioxidant status (TAS) and total oxidant status (TOS) levels were compared among groups. Mean TAS level (14.03 +/- 9.09 mmol/L) in the group with more than six months of symptoms had a tendency to be higher (p = 0.068) than that of the group with fewer than six months (12.33 +/- 8.83 mmol/L). There was no statistically significant difference in mean TAS or TOS level with number of symptoms (nasal congestion, itching, sneezing and watery rhinorrhea). A multivariate logistic regression showed that the adjusted odds ratio of TAS was 1.655 and the adjusted odds ratio of TOS was 0.972 in more than a six-month duration group. The TAS level was significantly associated with a more than six-month symptom duration (p = 0.034). Our results suggest that antioxidant activity increased when allergic rhinitis became chronic and further research will be needed considering the disease severity.
Author(s)
문현심창선이지호오인보안태훈이종철
Issued Date
2021
Type
Article
Keyword
allergic rhinitis total oxidant status total antioxidant status prospective study school children
DOI
10.3390/jpm11121290
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8524
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_5482c453895543e4a38fe516c9d65d52&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,A%20Prospective%20Study%20on%20the%20Association%20between%20Oxidative%20Stress%20and%20Duration%20of%20Symptoms%20in%20Allergic%20Rhinitis&offset=0&pcAvailability=true
Publisher
Journal of Personalized Medicine
Location
스위스
Language
영어
ISSN
2075-4426
Citation Volume
11
Citation Number
1290
Citation Start Page
1
Citation End Page
9
Appears in Collections:
Medicine > Medicine
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